Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes

Details

Serval ID
serval:BIB_BFB8C5543009
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes
Journal
Journal of Infectious Diseases
Author(s)
Cohen  O. J., Pantaleo  G., Holodniy  M., Fox  C. H., Orenstein  J. M., Schnittman  S., Niu  M., Graziosi  C., Pavlakis  G. N., Lalezari  J., Bartlett  J. A., Steigbigel  R. T., Cohn  J., Novak  R., McMahon  D., Bilello  J., Fauci  A. S.
ISSN
0022-1899 (Print)
Publication state
Published
Issued date
04/1996
Volume
173
Number
4
Pages
849-56
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S. --- Old month value: Apr
Abstract
Initiation of antiretroviral monotherapy early in the course of infection with human immunodeficiency virus may result in a temporary slowing in the rate of disease progression; however, little is known about the virologic effects of early therapy. Virus load was measured in peripheral blood and lymph nodes from 16 antiretroviral-naive patients with a mean CD4 T lymphocyte count of 659 cells/microliter at baseline and after 8 weeks of either no treatment or zidovudine therapy. CD4 T lymphocyte counts and all virologic parameters examined remained unchanged regardless of zidovudine treatment status. Histopathology and virus distribution within lymph nodes remained constant between baseline and week 8 in each patient, indicating that the virologic and histologic parameters examined in a single lymph node are representative of a systemic process. Early antiretroviral monotherapy with zidovudine had no effect on virologic parameters in this group of patients with relatively high CD4 T lymphocyte counts and low measures of virus load at baseline.
Keywords
Adult Antiviral Agents/*therapeutic use Base Sequence Biological Markers CD4 Lymphocyte Count DNA Primers/chemistry Female HIV/*growth & development HIV Infections/*drug therapy/microbiology HIV-1 Reverse Transcriptase Humans In Situ Hybridization Lymph Nodes/microbiology Male Molecular Sequence Data RNA-Directed DNA Polymerase/metabolism Reverse Transcriptase Inhibitors/*therapeutic use Time Factors Virus Replication Zidovudine/*therapeutic use
Pubmed
Web of science
Create date
25/01/2008 14:58
Last modification date
20/08/2019 15:34
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