Emerging Roles of Translational Control in Circadian Timekeeping.

Détails

Ressource 1Télécharger: JMB___Review___Circadian_Translation__accepted version.pdf (1570.03 [Ko])
Etat: Public
Version: de l'auteur⸱e
Licence: Non spécifiée
ID Serval
serval:BIB_A85C20DA0A13
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Emerging Roles of Translational Control in Circadian Timekeeping.
Périodique
Journal of molecular biology
Auteur⸱e⸱s
Castelo-Szekely V., Gatfield D.
ISSN
1089-8638 (Electronic)
ISSN-L
0022-2836
Statut éditorial
Publié
Date de publication
29/05/2020
Peer-reviewed
Oui
Volume
432
Numéro
12
Pages
3483-3497
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
A large part of mammalian physiology and behaviour shows regular daily variations. This temporal organisation is driven by the activity of an endogenous circadian clock, whose molecular basis consists of diurnal waves in gene expression. Circadian transcription is the major driver of these rhythms, yet post-transcriptional mechanisms, some of which occur in response to systemic cues and in a tissue-specific fashion, have central roles in ultimately establishing the oscillatory gene expression programme as well. Regulatory control that occurs at the level of translation is emerging as an important player in the generation and modulation of protein accumulation rhythms. As a mechanism, translation lies at a privileged position to integrate genetically encoded rhythmic signals with other, external and internal stimuli, including nutrient-derived cues. In this review, we summarise our current knowledge of how diurnal control of translation affects both bulk protein levels and gene-specific protein biosynthesis. We discuss mechanisms of regulation, in particular with regard to the complex interplay between circadian cycles and feeding/fasting cycles, as well as emerging roles for upstream open reading frames in clock control.
Mots-clé
circadian clock, feeding/fasting cycles, ribosome biogenesis, translation, uORFs
Pubmed
Web of science
Open Access
Oui
Création de la notice
08/04/2020 13:26
Dernière modification de la notice
21/11/2022 8:27
Données d'usage