Emerging Roles of Translational Control in Circadian Timekeeping.

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Serval ID
serval:BIB_A85C20DA0A13
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Emerging Roles of Translational Control in Circadian Timekeeping.
Journal
Journal of molecular biology
Author(s)
Castelo-Szekely V., Gatfield D.
ISSN
1089-8638 (Electronic)
ISSN-L
0022-2836
Publication state
Published
Issued date
29/05/2020
Peer-reviewed
Oui
Volume
432
Number
12
Pages
3483-3497
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
A large part of mammalian physiology and behaviour shows regular daily variations. This temporal organisation is driven by the activity of an endogenous circadian clock, whose molecular basis consists of diurnal waves in gene expression. Circadian transcription is the major driver of these rhythms, yet post-transcriptional mechanisms, some of which occur in response to systemic cues and in a tissue-specific fashion, have central roles in ultimately establishing the oscillatory gene expression programme as well. Regulatory control that occurs at the level of translation is emerging as an important player in the generation and modulation of protein accumulation rhythms. As a mechanism, translation lies at a privileged position to integrate genetically encoded rhythmic signals with other, external and internal stimuli, including nutrient-derived cues. In this review, we summarise our current knowledge of how diurnal control of translation affects both bulk protein levels and gene-specific protein biosynthesis. We discuss mechanisms of regulation, in particular with regard to the complex interplay between circadian cycles and feeding/fasting cycles, as well as emerging roles for upstream open reading frames in clock control.
Keywords
circadian clock, feeding/fasting cycles, ribosome biogenesis, translation, uORFs
Pubmed
Web of science
Open Access
Yes
Create date
08/04/2020 14:26
Last modification date
11/07/2020 6:18
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