The art of growing old: Environmental manipulation, physiological rhythms and the advent of Microcebus murinus as a primate model of aging

Détails

ID Serval
serval:BIB_8F3E89A5AEBE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The art of growing old: Environmental manipulation, physiological rhythms and the advent of Microcebus murinus as a primate model of aging
Périodique
History and Philosophy of the Life Sciences
Auteur(s)
Gerber L.
Statut éditorial
Publié
Date de publication
11/06/2020
Peer-reviewed
Oui
Volume
42
Numéro
26
Langue
anglais
Résumé
In the early 1990s, Microcebus murinus, a small primate endemic to Madagascar, emerged as a potential animal model for the study of aging and Alzheimer’s disease. This paper traces the use of the lesser mouse lemur in research on aging and associated neurodegenerative diseases, focusing on a basic material precondition that made this possible, namely, the conversion of a wild animal into an experimental organism that lives, breeds, and survives in the laboratory. It argues that the “old” mouse lemur model can be considered as an eco-zootechnical acquisition. This is shown by examining how, since the early 1970s, French mouse lemur researchers have articulated colony productivity and viability with the influence of environmental factors on the demographics and physiology of the species. The appearance and maintenance of a growing number of old mouse lemurs in French research facilities are related to three developments: the application of the ecological notion of “social stress” to the understanding and management of the behavior of the captive population; the experimental demonstration that a variety of seasonal physiological changes in the species were influenced by the photoperiod; and the related attempt to accelerate aging in mouse lemurs through the manipulation of annual light conditions.
Mots-clé
small primate model for aging research, closed-colony breeding and maintenance of prosimians, eco-physiology, social stress, biological rhythms studies, accelerated aging.
Création de la notice
30/01/2020 12:25
Dernière modification de la notice
12/06/2020 6:20
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