The art of growing old: Environmental manipulation, physiological rhythms and the advent of Microcebus murinus as a primate model of aging

Details

Serval ID
serval:BIB_8F3E89A5AEBE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The art of growing old: Environmental manipulation, physiological rhythms and the advent of Microcebus murinus as a primate model of aging
Journal
History and Philosophy of the Life Sciences
Author(s)
Gerber L.
Publication state
Published
Issued date
11/06/2020
Peer-reviewed
Oui
Volume
42
Number
26
Language
english
Abstract
In the early 1990s, Microcebus murinus, a small primate endemic to Madagascar, emerged as a potential animal model for the study of aging and Alzheimer’s disease. This paper traces the use of the lesser mouse lemur in research on aging and associated neurodegenerative diseases, focusing on a basic material precondition that made this possible, namely, the conversion of a wild animal into an experimental organism that lives, breeds, and survives in the laboratory. It argues that the “old” mouse lemur model can be considered as an eco-zootechnical acquisition. This is shown by examining how, since the early 1970s, French mouse lemur researchers have articulated colony productivity and viability with the influence of environmental factors on the demographics and physiology of the species. The appearance and maintenance of a growing number of old mouse lemurs in French research facilities are related to three developments: the application of the ecological notion of “social stress” to the understanding and management of the behavior of the captive population; the experimental demonstration that a variety of seasonal physiological changes in the species were influenced by the photoperiod; and the related attempt to accelerate aging in mouse lemurs through the manipulation of annual light conditions.
Keywords
small primate model for aging research, closed-colony breeding and maintenance of prosimians, eco-physiology, social stress, biological rhythms studies, accelerated aging.
Create date
30/01/2020 12:25
Last modification date
12/06/2020 6:20
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