Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis.

Détails

Ressource 1Télécharger: Chen2019_Gasdermin_review_EMBOJ_revision.pdf (542.88 [Ko])
Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_82D60FA890A5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis.
Périodique
The EMBO journal
Auteur(s)
Chen K.W., Demarco B., Broz P.
ISSN
1460-2075 (Electronic)
ISSN-L
0261-4189
Statut éditorial
Publié
Date de publication
15/01/2020
Peer-reviewed
Oui
Volume
39
Numéro
2
Pages
e103397
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Programmed cell death is a key mechanism involved in several biological processes ranging from development and homeostasis to immunity, where it promotes the removal of stressed, damaged, malignant or infected cells. Abnormalities in the pathways leading to initiation of cell death or removal of dead cells are consequently associated with a range of human diseases including infections, autoinflammatory disease, neurodegenerative disease and cancer. Apoptosis, pyroptosis and NETosis are three well-studied modes of cell death that were traditionally believed to be independent of one another, but emerging evidence indicates that there is extensive cross-talk between them, and that all three pathways can converge onto the activation of the same cell death effector-the pore-forming protein Gasdermin D (GSDMD). In this review, we highlight recent advances in gasdermin research, with a particular focus on the role of gasdermins in pyroptosis, NETosis and apoptosis, as well as cell type-specific consequences of gasdermin activation. In addition, we discuss controversies surrounding a related gasdermin family protein, Gasdermin E (GSDME), in mediating pyroptosis and secondary necrosis following apoptosis, chemotherapy and inflammasome activation.
Mots-clé
Apoptosis, Humans, Inflammasomes/metabolism, Intracellular Signaling Peptides and Proteins/immunology, Intracellular Signaling Peptides and Proteins/metabolism, Necrosis, Neoplasms/metabolism, Neoplasms/pathology, Neutrophils/metabolism, Neutrophils/pathology, Phosphate-Binding Proteins/immunology, Phosphate-Binding Proteins/metabolism, Pyroptosis, NETosis, apoptosis, gasdermin, inflammasome, pyroptosis
Pubmed
Web of science
Création de la notice
04/12/2019 22:54
Dernière modification de la notice
14/11/2020 8:09
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