Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis.

Details

Serval ID
serval:BIB_82D60FA890A5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis.
Journal
The EMBO journal
Author(s)
Chen K.W., Demarco B., Broz P.
ISSN
1460-2075 (Electronic)
ISSN-L
0261-4189
Publication state
Published
Issued date
15/01/2020
Peer-reviewed
Oui
Volume
39
Number
2
Pages
e103397
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Programmed cell death is a key mechanism involved in several biological processes ranging from development and homeostasis to immunity, where it promotes the removal of stressed, damaged, malignant or infected cells. Abnormalities in the pathways leading to initiation of cell death or removal of dead cells are consequently associated with a range of human diseases including infections, autoinflammatory disease, neurodegenerative disease and cancer. Apoptosis, pyroptosis and NETosis are three well-studied modes of cell death that were traditionally believed to be independent of one another, but emerging evidence indicates that there is extensive cross-talk between them, and that all three pathways can converge onto the activation of the same cell death effector-the pore-forming protein Gasdermin D (GSDMD). In this review, we highlight recent advances in gasdermin research, with a particular focus on the role of gasdermins in pyroptosis, NETosis and apoptosis, as well as cell type-specific consequences of gasdermin activation. In addition, we discuss controversies surrounding a related gasdermin family protein, Gasdermin E (GSDME), in mediating pyroptosis and secondary necrosis following apoptosis, chemotherapy and inflammasome activation.
Keywords
NETosis, apoptosis, gasdermin, inflammasome, pyroptosis
Pubmed
Web of science
Create date
04/12/2019 22:54
Last modification date
08/02/2020 7:17
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