A compliant small-diameter vascular prosthesis lined with functional venous endothelial cells

Détails

ID Serval
serval:BIB_72ED378A6C42
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A compliant small-diameter vascular prosthesis lined with functional venous endothelial cells
Périodique
ASAIO Transactions
Auteur⸱e⸱s
Muller-Glauser  W., Lehmann  K. H., Bittmann  P., Bay  U., Dittes  P., von Segesser  L., Turina  M.
ISSN
1058-2916
0889-7190
Statut éditorial
Publié
Date de publication
09/1988
Volume
34
Numéro
3
Pages
528-31
Notes
Journal Article --- Old month value: Jul-Sep
Résumé
The long-term patency of small-diameter vascular grafts is still unsatisfactory. In contrast to native arteries, they are inelastic and lack active antithrombogenicity. To improve long-term patency, a new 4 mm internal diameter prosthesis was developed which is compliant and lined with functional endothelial cells (ENC). The wall of this prosthesis consists of a microporous polyurethane-siloxane copolymer reinforced with a polyester network. It displays compliance (13.2 x 10(-4) mmHg-1) comparable to native arteries, is nonkinkable (minimum radius of curvature = 5 mm), burst resistant, and easily suturable. Using a lining procedure, coverage of prostheses by ENC was in excess of 95%. The ENC populations were found to be highly pure (by factor VIII-related antigen, DilAcLDL uptake) and to produce about 0.3 ng prostacyclin per cm2. In vitro tests of shear stress resistance demonstrated that ENC monolayers on the new elastic prosthesis remain intact for 3 hr in physiologically pulsating culture medium (Vmax = 50 cm/sec). Lined prostheses implanted for 24 hours in mongrel dogs as an arteriovenous shunt demonstrated the antithrombogenicity of the cultured ENC. The results suggest that small-diameter vascular prostheses which are compliant, porous, and actively antithrombogenic are feasible.
Mots-clé
Animals *Blood Vessel Prosthesis Compliance Dogs Endothelium, Vascular/*cytology/ultrastructure Evaluation Studies as Topic Humans Microscopy, Electron, Scanning Tensile Strength Vascular Patency Veins
Pubmed
Création de la notice
14/02/2008 14:17
Dernière modification de la notice
20/08/2019 14:31
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