A compliant small-diameter vascular prosthesis lined with functional venous endothelial cells

Details

Serval ID
serval:BIB_72ED378A6C42
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A compliant small-diameter vascular prosthesis lined with functional venous endothelial cells
Journal
ASAIO Transactions
Author(s)
Muller-Glauser  W., Lehmann  K. H., Bittmann  P., Bay  U., Dittes  P., von Segesser  L., Turina  M.
ISSN
1058-2916
0889-7190
Publication state
Published
Issued date
09/1988
Volume
34
Number
3
Pages
528-31
Notes
Journal Article --- Old month value: Jul-Sep
Abstract
The long-term patency of small-diameter vascular grafts is still unsatisfactory. In contrast to native arteries, they are inelastic and lack active antithrombogenicity. To improve long-term patency, a new 4 mm internal diameter prosthesis was developed which is compliant and lined with functional endothelial cells (ENC). The wall of this prosthesis consists of a microporous polyurethane-siloxane copolymer reinforced with a polyester network. It displays compliance (13.2 x 10(-4) mmHg-1) comparable to native arteries, is nonkinkable (minimum radius of curvature = 5 mm), burst resistant, and easily suturable. Using a lining procedure, coverage of prostheses by ENC was in excess of 95%. The ENC populations were found to be highly pure (by factor VIII-related antigen, DilAcLDL uptake) and to produce about 0.3 ng prostacyclin per cm2. In vitro tests of shear stress resistance demonstrated that ENC monolayers on the new elastic prosthesis remain intact for 3 hr in physiologically pulsating culture medium (Vmax = 50 cm/sec). Lined prostheses implanted for 24 hours in mongrel dogs as an arteriovenous shunt demonstrated the antithrombogenicity of the cultured ENC. The results suggest that small-diameter vascular prostheses which are compliant, porous, and actively antithrombogenic are feasible.
Keywords
Animals *Blood Vessel Prosthesis Compliance Dogs Endothelium, Vascular/*cytology/ultrastructure Evaluation Studies as Topic Humans Microscopy, Electron, Scanning Tensile Strength Vascular Patency Veins
Pubmed
Create date
14/02/2008 15:17
Last modification date
20/08/2019 15:31
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