Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.

Karlsson Linnér, R.; Biroli, P.; Kong, E.; Meddens, SFW; Wedow, R.; Fontana, M.A.; Lebreton, M.; Tino, S.P.; Abdellaoui, A.; Hammerschlag, A.R.; Nivard, M.G.; Okbay, A.; Rietveld, C.A.; Timshel, P.N.; Trzaskowski, M.; Vlaming, R.; Zünd, C.L.; Bao, Y.; Buzdugan, L.; Caplin, A.H.; Chen, C.Y.; Eibich, P.; Fontanillas, P.; Gonzalez, J.R.; Joshi, P.K.; Karhunen, V.; Kleinman, A.; Levin, R.Z.; Lill, C.M.; Meddens, G.A.; Muntané, G.; Sanchez-Roige, S.; Rooij, FJV; Taskesen, E.; Wu, Y.; Zhang, F.; Auton, A.; Boardman, J.D.; Clark, D.W.; Conlin, A.; Dolan, C.C.; Fischbacher, U.; Groenen, PJF; Harris, K.M.; Hasler, G.; Hofman, A.; Ikram, M.A.; Jain, S.; Karlsson, R.; Kessler, R.C.; Kooyman, M.; MacKillop, J.; Männikkö, M.; Morcillo-Suarez, C.; McQueen, M.B.; Schmidt, K.M.; Smart, M.C.; Sutter, M.; Thurik, A.R.; Uitterlinden, A.G.; White, J.; Wit, H.; Yang, J.; Bertram, L.; Boomsma, D.I.; Esko, T.; Fehr, E.; Hinds, D.A.; Johannesson, M.; Kumari, M.; Laibson, D.; Magnusson, PKE; Meyer, M.N.; Navarro, A.; Palmer, A.A.; Pers, T.H.; Posthuma, D.; Schunk, D.; Stein, M.B.; Svento, R.; Tiemeier, H.; Timmers, PRHJ; Turley, P.; Ursano, R.J.; Wagner, G.G.; Wilson, J.F.; Gratten, J.; Lee, J.J.; Cesarini, D.; Benjamin, D.J.; Koellinger, P.D.; Beauchamp, J.P.

doi:10.1038/s41588-018-0309-3

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.

Détails

Télécharger: Linnen.pdf (1243.20 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0

Document(s) secondaire(s)

Télécharger: Linnen 1.pdf (18934.00 [Ko])
Etat: Public
Version: Supplementary document
Licence: Non spécifiée

Télécharger: Linnen 2.pdf (10925.58 [Ko])
Etat: Public
Version: Supplementary document
Licence: CC BY 4.0

Télécharger: Linnen 3.xlsx (2361.28 [Ko])
Etat: Public
Version: Supplementary document
Licence: CC BY 4.0

ID Serval

serval:BIB_48844D716164

Type

Article: article d'un périodique ou d'un magazine.

Collection

Publications

Institution

UNIL/CHUV

Titre

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.

Périodique

Nature genetics

Auteur⸱e⸱s

Karlsson Linnér R., Biroli P., Kong E., Meddens SFW, Wedow R., Fontana M.A., Lebreton M., Tino S.P., Abdellaoui A., Hammerschlag A.R., Nivard M.G., Okbay A., Rietveld C.A., Timshel P.N., Trzaskowski M., Vlaming R., Zünd C.L., Bao Y., Buzdugan L., Caplin A.H., Chen C.Y., Eibich P., Fontanillas P., Gonzalez J.R., Joshi P.K., Karhunen V., Kleinman A., Levin R.Z., Lill C.M., Meddens G.A., Muntané G., Sanchez-Roige S., Rooij FJV, Taskesen E., Wu Y., Zhang F., Auton A., Boardman J.D., Clark D.W., Conlin A., Dolan C.C., Fischbacher U., Groenen PJF, Harris K.M., Hasler G., Hofman A., Ikram M.A., Jain S., Karlsson R., Kessler R.C., Kooyman M., MacKillop J., Männikkö M., Morcillo-Suarez C., McQueen M.B., Schmidt K.M., Smart M.C., Sutter M., Thurik A.R., Uitterlinden A.G., White J., Wit H., Yang J., Bertram L., Boomsma D.I., Esko T., Fehr E., Hinds D.A., Johannesson M., Kumari M., Laibson D., Magnusson PKE, Meyer M.N., Navarro A., Palmer A.A., Pers T.H., Posthuma D., Schunk D., Stein M.B., Svento R., Tiemeier H., Timmers PRHJ, Turley P., Ursano R.J., Wagner G.G., Wilson J.F., Gratten J., Lee J.J., Cesarini D., Benjamin D.J., Koellinger P.D., Beauchamp J.P.

Collaborateur⸱rice⸱s

23and Me Research Team, eQTLgen Consortium, International Cannabis Consortium, Social Science Genetic Association Consortium

Contributeur⸱rice⸱s

Agee M., Alipanahi B., Bell R.K., Bryc K., Elson S.L., Furlotte N.A., Huber K.E., Litterman N.K., McCreight J.C., McIntyre M.H., Mountain J.L., Northover CAM, Pitts S.J., Sathirapongsasuti J.F., Sazonova O.V., Shelton J.F., Shringarpure S., Tian C., Tung J.Y., Vacic V., Wilson C.H., Agbessi M., Ahsan H., Alves I., Andiappan A., Awadalla P., Battle A., Beutner F., Jan Bonder M., Boomsma D.I., Christiansen M., Claringbould A., Deelen P., Esko T., Favé M.J., Franke L., Frayling T., Gharib S.A., Gibson G., Heijmans B., Hemani G., Jansen R., Kähönen M., Kalnapenkis A., Kasela S., Kettunen J., Kim Y., Kirsten H., Kovacs P., Krohn K., Kronberg-Guzman J., Kukushkina V., Kutalik Z., Lee B., Lehtimäki T., Loeffler M., Marigorta U.M., Metspalu A., Milani L., Montgomery G.W., Müller-Nurasyid M., Nauck M., Nivard M.G., Penninx B., Perola M., Pervjakova N., Pierce B., Powell J., Prokisch H., Psaty B.M., Raitakari O., Ring S., Ripatti S., Rotzchke O., Rüeger S., Saha A., Scholz M., Schramm K., Seppälä I., Stumvoll M., Sullivan P., Hoen P.T., Teumer A., Thiery J., Tong L., Tönjes A., Dongen J.V., Meurs J.V., Verlouw J., Visscher P.M., Völker U., Võsa U., Westra H.J., Yaghootkar H., Yang J., Zeng B., Zhang F., Okbay A., Beauchamp J.P., Fontana M.A., Lee J.J., Pers T.H., Rietveld C.A., Turley P., Chen G.B., Emilsson V., Meddens SFW, Oskarsson S., Pickrell J.K., Thom K., Timshel P., de Vlaming R., Abdellaoui A., Ahluwalia T.S., Bacelis J., Baumbach C., Bjornsdottir G., Brandsma J.H., Concas M.P., Derringer J., Furlotte N.A., Galesloot T.E., Girotto G., Gupta R., Hall L.M., Harris S.E., Hofer E., Horikoshi M., Huffman J.E., Kaasik K., Kalafati I.P., Karlsson R., Kong A., Lahti J., Lee SJV, de Leeuw C., Lind P.A., Lindgren K.O., Liu T., Mangino M., Marten J., Mihailov E., Miller M.B., Most PJV, Oldmeadow C., Payton A., Pervjakova N., Peyrot W.J., Qian Y., Raitakari O., Rueedi R., Salvi E., Schmidt B., Schraut K.E., Shi J., Smith A.V., Poot R.A., Pourcain B.S., Teumer A., Thorleifsson G., Verweij N., Vuckovic D., Wellmann J., Westra H.J., Yang J., Zhao W., Zhu Z., Alizadeh B.Z., Amin N., Bakshi A., Baumeister S.E., Biino G., Bønnelykke K., Boyle P.A., Campbell H., Cappuccio F.P., Davies G., De Neve J.E., Deloukas P., Demuth I., Ding J., Eibich P., Eisele L., Eklund N., Evans D.M., Faul J.D., Feitosa M.F., Forstner A.J., Gandin I., Gunnarsson B., Halldórsson B.V., Harris T.B., Heath A.C., Hocking L.J., Holliday E.G., Homuth G., Horan M.A., Hottenga J.J., de Jager P.L., Joshi P.K., Jugessur A., Kaakinen M.A., Kähönen M., Kanoni S., Keltigangas-Järvinen L., Kiemeney LALM, Kolcic I., Koskinen S., Kraja A.T., Kroh M., Kutalik Z., Latvala A., Launer L.J., Lebreton M.P., Levinson D.F., Lichtenstein P., Lichtner P., Liewald DCM, Loukola A., Madden P.A., Mägi R., Mäki-Opas T., Marioni R.E., Marques-Vidal P., Meddens G.A., McMahon G., Meisinger C., Meitinger T., Milaneschi Y., Milani L., Montgomery G.W., Myhre R., Nelson C.P., Nyholt D.R., Ollier WER, Palotie A., Paternoster L., Pedersen N.L., Petrovic K.E., Porteous D.J., Räikkönen K., Ring S.M., Robino A., Rostapshova O., Rudan I., Rustichini A., Salomaa V., Sanders A.R., Sarin A.P., Schmidt H., Scott R.J., Smith B.H., Smith J.A., Staessen J.A., Steinhagen-Thiessen E., Strauch K., Terracciano A., Tobin M.D., Ulivi S., Vaccargiu S., Quaye L., Rooij FJV, Venturini C., Vinkhuyzen AAE, Völker U., Völzke H., Vonk J.M., Vozzi D., Waage J., Ware E.B., Willemsen G., Attia J.R., Bennett D.A., Berger K., Bertram L., Bisgaard H., Boomsma D.I., Borecki I.B., Bültmann U., Chabris C.F., Cucca F., Cusi D., Deary I.J., Dedoussis G.V., Duijn CMV, Eriksson J.G., Franke B., Franke L., Gasparini P., Gejman P.V., Gieger C., Grabe H.J., Gratten J., Groenen PJF, Gudnason V., Harst P.V., Hayward C., Hinds D.A., Hoffmann W., Hyppönen E., Iacono W.G., Jacobsson B., Järvelin M.R., Jöckel K.H., Kaprio J., Kardia SLR, Lehtimäki T., Lehrer S.F., Magnusson PKE, Martin N.G., McGue M., Metspalu A., Pendleton N., Penninx B., Perola M., Pirastu N., Pirastu M., Polasek O., Posthuma D., Power C., Province M.A., Samani N.J., Schlessinger D., Schmidt R., Sørensen TIA, Spector T.D., Stefansson K., Thorsteinsdottir U., Thurik A.R., Timpson N.J., Tiemeier H., Tung J.Y., Uitterlinden A.G., Vitart V., Vollenweider P., Weir D.R., Wilson J.F., Wright A.F., Conley D.C., Krueger R.F., Smith G.D., Hofman A., Laibson D.I., Medland S.E., Meyer M.N., Yang J., Johannesson M., Visscher P.M., Esko T., Koellinger P.D., Cesarini D., Benjamin D.J.

ISSN

1546-1718 (Electronic)

ISSN-L

1061-4036

Statut éditorial

Publié

Date de publication

02/2019

Peer-reviewed

Oui

Volume

Numéro

Pages

245-257

Langue

anglais

Notes

Publication types: Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
Publication Status: ppublish

Résumé

Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated ([Formula: see text] ~ 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.

Mots-clé

Behavior/physiology, Case-Control Studies, Female, Genetic Loci/genetics, Genetic Predisposition to Disease/genetics, Genetics, Behavioral/methods, Genome-Wide Association Study/methods, Genotype, Humans, Male, Polymorphism, Single Nucleotide/genetics

URN

urn:nbn:ch:serval-BIB_48844D7161647

OAI-PMH

oai:serval.unil.ch:BIB_48844D716164

DOI

10.1038/s41588-018-0309-3

Pubmed

30643258

Web of science

000457314300011

Création de la notice

25/01/2019 9:33