Astrocyte function from information processing to cognition and cognitive impairment.

Détails

Ressource 1Télécharger: 30664773Santello et al Nat Neurosci 2019.pdf (2155.62 [Ko])
Etat: Public
Version: Author's accepted manuscript
Licence: Tous droits réservés
ID Serval
serval:BIB_3B247F87F528
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Astrocyte function from information processing to cognition and cognitive impairment.
Périodique
Nature neuroscience
Auteur⸱e⸱s
Santello M., Toni N., Volterra A.
ISSN
1546-1726 (Electronic)
ISSN-L
1097-6256
Statut éditorial
Publié
Date de publication
02/2019
Peer-reviewed
Oui
Volume
22
Numéro
2
Pages
154-166
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Astrocytes serve important roles that affect recruitment and function of neurons at the local and network levels. Here we review the contributions of astrocyte signaling to synaptic plasticity, neuronal network oscillations, and memory function. The roles played by astrocytes are not fully understood, but astrocytes seem to contribute to memory consolidation and seem to mediate the effects of vigilance and arousal on memory performance. Understanding the role of astrocytes in cognitive processes may also advance our understanding of how these processes go awry in pathological conditions. Indeed, abnormal astrocytic signaling can cause or contribute to synaptic and network imbalances, leading to cognitive impairment. We discuss evidence for this from animal models of Alzheimer's disease and multiple sclerosis and from animal studies of sleep deprivation and drug abuse and addiction. Understanding the emerging roles of astrocytes in cognitive function and dysfunction will open up a large array of new therapeutic opportunities.
Mots-clé
Animals, Astrocytes/physiology, Brain/pathology, Brain/physiopathology, Cognition/physiology, Cognitive Dysfunction/pathology, Cognitive Dysfunction/physiopathology, Humans, Memory/physiology, Neuronal Plasticity/physiology, Neurons/pathology, Neurons/physiology
Pubmed
Web of science
Création de la notice
31/01/2019 10:22
Dernière modification de la notice
21/11/2022 9:26
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