Astrocyte function from information processing to cognition and cognitive impairment.

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Ressource 1Download: 30664773Santello et al Nat Neurosci 2019.pdf (2155.62 [Ko])
State: Public
Version: Author's accepted manuscript
License: All rights reserved
Serval ID
serval:BIB_3B247F87F528
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Astrocyte function from information processing to cognition and cognitive impairment.
Journal
Nature neuroscience
Author(s)
Santello M., Toni N., Volterra A.
ISSN
1546-1726 (Electronic)
ISSN-L
1097-6256
Publication state
Published
Issued date
02/2019
Peer-reviewed
Oui
Volume
22
Number
2
Pages
154-166
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Astrocytes serve important roles that affect recruitment and function of neurons at the local and network levels. Here we review the contributions of astrocyte signaling to synaptic plasticity, neuronal network oscillations, and memory function. The roles played by astrocytes are not fully understood, but astrocytes seem to contribute to memory consolidation and seem to mediate the effects of vigilance and arousal on memory performance. Understanding the role of astrocytes in cognitive processes may also advance our understanding of how these processes go awry in pathological conditions. Indeed, abnormal astrocytic signaling can cause or contribute to synaptic and network imbalances, leading to cognitive impairment. We discuss evidence for this from animal models of Alzheimer's disease and multiple sclerosis and from animal studies of sleep deprivation and drug abuse and addiction. Understanding the emerging roles of astrocytes in cognitive function and dysfunction will open up a large array of new therapeutic opportunities.
Keywords
Animals, Astrocytes/physiology, Brain/pathology, Brain/physiopathology, Cognition/physiology, Cognitive Dysfunction/pathology, Cognitive Dysfunction/physiopathology, Humans, Memory/physiology, Neuronal Plasticity/physiology, Neurons/pathology, Neurons/physiology
Pubmed
Web of science
Create date
31/01/2019 9:22
Last modification date
20/08/2019 13:31
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