Malignant blue naevus with distant subcutaneous metastasis
Détails
ID Serval
serval:BIB_39948EACC13C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Malignant blue naevus with distant subcutaneous metastasis
Périodique
Clinical and Experimental Dermatology
ISSN
0307-6938 (Print)
Statut éditorial
Publié
Date de publication
11/1996
Volume
21
Numéro
6
Pages
427-30
Notes
Case Reports
Journal Article --- Old month value: Nov
Journal Article --- Old month value: Nov
Résumé
Malignant blue naevus is a distinct but rarely documented variant of malignant melanoma, and we describe the triple recurrence of a suprapatellar cellular blue naevus over 12 years in a middle-aged woman. Staging investigations revealed a distant subcutaneous metastasis of the right thigh. Immunohistochemistry of the primary lesion and all recurrences showed S-100, HMB-45, NKI/C-3 and Ki-67 positive cells. However, non-malignant cellular blue naevi from five consecutive other patients were all Ki-67 negative. The change from negative to positive Ki-67 responsivity may therefore be a valuable marker of malignant and metastatic potential in early cellular blue naevi.
Mots-clé
Female
Humans
Immunohistochemistry
Leg
Magnetic Resonance Imaging
Middle Aged
Neoplasm Recurrence, Local/*pathology/radionuclide imaging
Nevus, Blue/pathology/radionuclide imaging/*secondary
Skin Neoplasms/*pathology/radionuclide imaging
Soft Tissue Neoplasms/pathology/radionuclide imaging/*secondary
Thigh
Tomography, Emission-Computed
Pubmed
Web of science
Création de la notice
25/01/2008 17:54
Dernière modification de la notice
20/08/2019 14:29