Malignant blue naevus with distant subcutaneous metastasis
Details
Serval ID
serval:BIB_39948EACC13C
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Malignant blue naevus with distant subcutaneous metastasis
Journal
Clinical and Experimental Dermatology
ISSN
0307-6938 (Print)
Publication state
Published
Issued date
11/1996
Volume
21
Number
6
Pages
427-30
Notes
Case Reports
Journal Article --- Old month value: Nov
Journal Article --- Old month value: Nov
Abstract
Malignant blue naevus is a distinct but rarely documented variant of malignant melanoma, and we describe the triple recurrence of a suprapatellar cellular blue naevus over 12 years in a middle-aged woman. Staging investigations revealed a distant subcutaneous metastasis of the right thigh. Immunohistochemistry of the primary lesion and all recurrences showed S-100, HMB-45, NKI/C-3 and Ki-67 positive cells. However, non-malignant cellular blue naevi from five consecutive other patients were all Ki-67 negative. The change from negative to positive Ki-67 responsivity may therefore be a valuable marker of malignant and metastatic potential in early cellular blue naevi.
Keywords
Female
Humans
Immunohistochemistry
Leg
Magnetic Resonance Imaging
Middle Aged
Neoplasm Recurrence, Local/*pathology/radionuclide imaging
Nevus, Blue/pathology/radionuclide imaging/*secondary
Skin Neoplasms/*pathology/radionuclide imaging
Soft Tissue Neoplasms/pathology/radionuclide imaging/*secondary
Thigh
Tomography, Emission-Computed
Pubmed
Web of science
Create date
25/01/2008 16:54
Last modification date
20/08/2019 13:29