Gas chromatographic identification and quantification of hydroxyzine: application in a fatal self-poisoning.

Détails

ID Serval
serval:BIB_0F7E3C3724F0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Gas chromatographic identification and quantification of hydroxyzine: application in a fatal self-poisoning.
Périodique
Forensic Science International
Auteur(s)
Kintz P., Godelar B., Mangin P.
ISSN
0379-0738[print], 0379-0738[linking]
Statut éditorial
Publié
Date de publication
1990
Volume
48
Numéro
2
Pages
139-143
Langue
anglais
Résumé
A method for the identification and quantification of hydroxyzine in human fluids by GC/NPD is presented. The method employs acepromazine as the internal standard and requires no derivatization. After a single alkaline extraction in n-heptane isoamylalcohol (98.5:1.5, v/v), analysis is achieved in 7 min. The lower limit of detectability was 0.8 ng/ml in plasma. Capillary gas chromatography mass spectrometry assay was developed for confirmation. Toxicological findings, after a fatality involving hydroxyzine are presented as an application of the procedure.
Mots-clé
Adolescent, Chromatography, Gas, Female, Gas Chromatography-Mass Spectrometry, Humans, Hydroxyzine/analysis, Hydroxyzine/blood, Reproducibility of Results, Suicide
Pubmed
Création de la notice
15/10/2010 16:14
Dernière modification de la notice
20/08/2019 13:36
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