Gas chromatographic identification and quantification of hydroxyzine: application in a fatal self-poisoning.
Details
Serval ID
serval:BIB_0F7E3C3724F0
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Gas chromatographic identification and quantification of hydroxyzine: application in a fatal self-poisoning.
Journal
Forensic Science International
ISSN
0379-0738[print], 0379-0738[linking]
Publication state
Published
Issued date
1990
Volume
48
Number
2
Pages
139-143
Language
english
Abstract
A method for the identification and quantification of hydroxyzine in human fluids by GC/NPD is presented. The method employs acepromazine as the internal standard and requires no derivatization. After a single alkaline extraction in n-heptane isoamylalcohol (98.5:1.5, v/v), analysis is achieved in 7 min. The lower limit of detectability was 0.8 ng/ml in plasma. Capillary gas chromatography mass spectrometry assay was developed for confirmation. Toxicological findings, after a fatality involving hydroxyzine are presented as an application of the procedure.
Keywords
Adolescent, Chromatography, Gas, Female, Gas Chromatography-Mass Spectrometry, Humans, Hydroxyzine/analysis, Hydroxyzine/blood, Reproducibility of Results, Suicide
Pubmed
Create date
15/10/2010 16:14
Last modification date
20/08/2019 13:36
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