Inflammation-induced changes in expression and glycosylation of genetic variants of alpha 1-acid glycoprotein. Studies with human sera, primary cultures of human hepatocytes and transgenic mice.

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State: Public
Version: author
Serval ID
serval:BIB_D91F15A791FA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Inflammation-induced changes in expression and glycosylation of genetic variants of alpha 1-acid glycoprotein. Studies with human sera, primary cultures of human hepatocytes and transgenic mice.
Journal
Biochemical Journal
Author(s)
van Dijk W., Pos O., van der Stelt M.E., Moshage H.J., Yap S.H., Dente L., Baumann P., Eap C.B.
ISSN
0264-6021 (Print)
ISSN-L
0264-6021
Publication state
Published
Issued date
1991
Peer-reviewed
Oui
Volume
276 ( Pt 2)
Pages
343-347
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
The relative occurrence of genetic variants of human alpha 1-acid glycoprotein (AGP) in relation to changes in glycosylation was studied in sera of patients with burn injury, media of cytokine-treated primary cultures of human hepatocytes and Hep 3B cells, and sera of transgenic mice expressing the human AGP-A gene. It is concluded (i) that the glycosylation of AGP was not dependent on its genetic expression and (ii) that both the variants determined by the AGP-A gene as well as by the AGP-B/B' genes are increased after inflammation or treatment with interleukins 1 and 6.
Keywords
Animals, Burns/blood, Burns/physiopathology, Carcinoma, Hepatocellular, Cells, Cultured, Cytokines/pharmacology, Gene Expression, Genetic Variation, Glycosylation, Humans, Inflammation, Liver/drug effects, Liver/metabolism, Liver Neoplasms, Mice, Mice, Transgenic, Orosomucoid/analysis, Orosomucoid/biosynthesis
Pubmed
Web of science
Create date
01/03/2013 10:14
Last modification date
20/08/2019 15:58
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