Roles of superantigens in microbial infections?

Details

Serval ID
serval:BIB_CAD8C9943F0D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Roles of superantigens in microbial infections?
Journal
Research in Immunology
Author(s)
Acha-Orbea H.
ISSN
0923-2494 (Print)
ISSN-L
0923-2494
Publication state
Published
Issued date
1993
Volume
144
Number
3
Pages
198-201; discussion 214-22
Language
english
Abstract
Superantigens have been defined in a variety of infectious particles such as bacteria and viruses. These superantigens have the capacity to stimulate a large percentage of the host T cells by interacting specifically with the T-cell receptor V beta chain which is shared by about 1-20% of mature T cells. The recent discovery that mammary tumour viruses express such superantigens enabled the analysis of the retroviral life cycle and led to questions about the role of superantigen in amplification of the infection.
Keywords
Animals, Bacterial Infections/immunology, Lymphocyte Activation, Mice, Minor Lymphocyte Stimulatory Antigens/immunology, Receptors, Antigen, T-Cell, alpha-beta/immunology, Superantigens/immunology, T-Lymphocytes/immunology, Virus Diseases/immunology
Pubmed
Web of science
Create date
24/01/2008 15:47
Last modification date
20/08/2019 16:45
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