The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis.

Details

Serval ID
serval:BIB_C1F31C62ECAE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis.
Journal
Ocular immunology and inflammation
Author(s)
Agrawal R., Gunasekeran D.V., Agarwal A., Carreño E., Aggarwal K., Gupta B., Raje D., Murthy S.I., Westcott M., Chee S.P., McCluskey P., Ling H.S., Teoh S., Cimino L., Biswas J., Narain S., Agarwal M., Mahendradas P., Khairallah M., Jones N., Tugal-Tutkun I., Babu K., Basu S., Lee R., Al-Dhibi H., Bodaghi B., Invernizzi A., Goldstein D.A., Herbort C.P., Barisani-Asenbauer T., González-López J.J., Androudi S., Bansal R., Moharana B., Mahajan S., Esposti S., Tasiopoulou A., Nadarajah S., Agarwal M., Abraham S., Vala R., Lord J., Singh R., Sharma A., Sharma K., Zierhut M., Kon O.M., Kempen J., Cunningham E.T., Rousselot A., Nguyen Q.D., Pavesio C., Gupta V.
ISSN
1744-5078 (Electronic)
ISSN-L
0927-3948
Publication state
In Press
Peer-reviewed
Oui
Pages
1-11
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU).
Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed.
245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13.5%), multifocal choroiditis (MFC) (9.4%), ampiginous choroiditis (9%), among others. 219 patients were treated with anti-tubercular therapy (ATT) (n = 219/245, 89.38%), 229 patients with steroids (n = 229/245, 93.47%) and 28 patients with immunosuppressive agents (n = 28/245, 11.42%). Treatment failure was noted in 38 patients (n = 38/245, 15.5%). Patients with SLC and ampiginous choroiditis appeared to have superior outcomes on survival analysis (p = 0.06).
This study provides a comprehensive description of choroidal involvement in TBU. Patients with SLC and ampiginous choroiditis may have better clinical outcomes.
Keywords
Anti-tubercular therapy, choroiditis, ocular, tuberculosis, uveitis
Pubmed
Create date
03/09/2018 13:00
Last modification date
05/08/2020 5:26
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