The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis.

Détails

ID Serval
serval:BIB_C1F31C62ECAE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis.
Périodique
Ocular immunology and inflammation
Auteur⸱e⸱s
Agrawal R., Gunasekeran D.V., Agarwal A., Carreño E., Aggarwal K., Gupta B., Raje D., Murthy S.I., Westcott M., Chee S.P., McCluskey P., Ling H.S., Teoh S., Cimino L., Biswas J., Narain S., Agarwal M., Mahendradas P., Khairallah M., Jones N., Tugal-Tutkun I., Babu K., Basu S., Lee R., Al-Dhibi H., Bodaghi B., Invernizzi A., Goldstein D.A., Herbort C.P., Barisani-Asenbauer T., González-López J.J., Androudi S., Bansal R., Moharana B., Mahajan S., Esposti S., Tasiopoulou A., Nadarajah S., Agarwal M., Abraham S., Vala R., Lord J., Singh R., Sharma A., Sharma K., Zierhut M., Kon O.M., Kempen J., Cunningham E.T., Rousselot A., Nguyen Q.D., Pavesio C., Gupta V.
ISSN
1744-5078 (Electronic)
ISSN-L
0927-3948
Statut éditorial
Publié
Date de publication
30/09/2020
Peer-reviewed
Oui
Volume
28
Numéro
sup1
Pages
38-48
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Purpose: To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU).Methods: Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed.Results: 245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13.5%), multifocal choroiditis (MFC) (9.4%), ampiginous choroiditis (9%), among others. 219 patients were treated with anti-tubercular therapy (ATT) (n = 219/245, 89.38%), 229 patients with steroids (n = 229/245, 93.47%) and 28 patients with immunosuppressive agents (n = 28/245, 11.42%). Treatment failure was noted in 38 patients (n = 38/245, 15.5%). Patients with SLC and ampiginous choroiditis appeared to have superior outcomes on survival analysis (p = 0.06).Conclusion: This study provides a comprehensive description of choroidal involvement in TBU. Patients with SLC and ampiginous choroiditis may have better clinical outcomes.
Mots-clé
Anti-tubercular therapy, choroiditis, ocular, tuberculosis, uveitis
Pubmed
Web of science
Création de la notice
03/09/2018 14:00
Dernière modification de la notice
02/02/2023 7:52
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