The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis.

Agrawal, R.; Gunasekeran, D.V.; Agarwal, A.; Carreño, E.; Aggarwal, K.; Gupta, B.; Raje, D.; Murthy, S.I.; Westcott, M.; Chee, S.P.; McCluskey, P.; Ling, H.S.; Teoh, S.; Cimino, L.; Biswas, J.; Narain, S.; Agarwal, M.; Mahendradas, P.; Khairallah, M.; Jones, N.; Tugal-Tutkun, I.; Babu, K.; Basu, S.; Lee, R.; Al-Dhibi, H.; Bodaghi, B.; Invernizzi, A.; Goldstein, D.A.; Herbort, C.P.; Barisani-Asenbauer, T.; González-López, J.J.; Androudi, S.; Bansal, R.; Moharana, B.; Mahajan, S.; Esposti, S.; Tasiopoulou, A.; Nadarajah, S.; Agarwal, M.; Abraham, S.; Vala, R.; Lord, J.; Singh, R.; Sharma, A.; Sharma, K.; Zierhut, M.; Kon, O.M.; Kempen, J.; Cunningham, E.T.; Rousselot, A.; Nguyen, Q.D.; Pavesio, C.; Gupta, V.

doi:10.1080/09273948.2018.1489061

The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis.

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Serval ID

serval:BIB_C1F31C62ECAE

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis.

Journal

Ocular immunology and inflammation

Author(s)

Agrawal R., Gunasekeran D.V., Agarwal A., Carreño E., Aggarwal K., Gupta B., Raje D., Murthy S.I., Westcott M., Chee S.P., McCluskey P., Ling H.S., Teoh S., Cimino L., Biswas J., Narain S., Agarwal M., Mahendradas P., Khairallah M., Jones N., Tugal-Tutkun I., Babu K., Basu S., Lee R., Al-Dhibi H., Bodaghi B., Invernizzi A., Goldstein D.A., Herbort C.P., Barisani-Asenbauer T., González-López J.J., Androudi S., Bansal R., Moharana B., Mahajan S., Esposti S., Tasiopoulou A., Nadarajah S., Agarwal M., Abraham S., Vala R., Lord J., Singh R., Sharma A., Sharma K., Zierhut M., Kon O.M., Kempen J., Cunningham E.T., Rousselot A., Nguyen Q.D., Pavesio C., Gupta V.

ISSN

1744-5078 (Electronic)

ISSN-L

0927-3948

Publication state

Published

Issued date

30/09/2020

Peer-reviewed

Oui

Volume

Number

sup1

Pages

38-48

Language

english

Notes

Publication types: Journal Article
Publication Status: ppublish

Abstract

Purpose: To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU).Methods: Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed.Results: 245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13.5%), multifocal choroiditis (MFC) (9.4%), ampiginous choroiditis (9%), among others. 219 patients were treated with anti-tubercular therapy (ATT) (n = 219/245, 89.38%), 229 patients with steroids (n = 229/245, 93.47%) and 28 patients with immunosuppressive agents (n = 28/245, 11.42%). Treatment failure was noted in 38 patients (n = 38/245, 15.5%). Patients with SLC and ampiginous choroiditis appeared to have superior outcomes on survival analysis (p = 0.06).Conclusion: This study provides a comprehensive description of choroidal involvement in TBU. Patients with SLC and ampiginous choroiditis may have better clinical outcomes.

Keywords

Anti-tubercular therapy, choroiditis, ocular, tuberculosis, uveitis

OAI-PMH

oai:serval.unil.ch:BIB_C1F31C62ECAE

DOI

10.1080/09273948.2018.1489061

Pubmed

30156979

Web of science

000840085900011

Create date

03/09/2018 14:00