Performance of 18F-FET versus 18F-FDG-PET for the diagnosis and grading of brain tumors: systematic review and meta-analysis.

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Version: Supplementary document
Serval ID
serval:BIB_C1621CCB076D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Performance of 18F-FET versus 18F-FDG-PET for the diagnosis and grading of brain tumors: systematic review and meta-analysis.
Journal
Neuro-oncology
Author(s)
Dunet V., Pomoni A., Hottinger A., Nicod-Lalonde M., Prior J.O.
ISSN
1523-5866 (Electronic)
ISSN-L
1522-8517
Publication state
Published
Issued date
03/2016
Peer-reviewed
Oui
Volume
18
Number
3
Pages
426-434
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Review

Abstract
For the past decade (18)F-fluoro-ethyl-l-tyrosine (FET) and (18)F-fluoro-deoxy-glucose (FDG) positron emission tomography (PET) have been used for the assessment of patients with brain tumor. However, direct comparison studies reported only limited numbers of patients. Our purpose was to compare the diagnostic performance of FET and FDG-PET.
We examined studies published between January 1995 and January 2015 in the PubMed database. To be included the study should: (i) use FET and FDG-PET for the assessment of patients with isolated brain lesion and (ii) use histology as the gold standard. Analysis was performed on a per patient basis. Study quality was assessed with STARD and QUADAS criteria.
Five studies (119 patients) were included. For the diagnosis of brain tumor, FET-PET demonstrated a pooled sensitivity of 0.94 (95% CI: 0.79-0.98) and pooled specificity of 0.88 (95% CI: 0.37-0.99), with an area under the curve of 0.96 (95% CI: 0.94-0.97), a positive likelihood ratio (LR+) of 8.1 (95% CI: 0.8-80.6), and a negative likelihood ratio (LR-) of 0.07 (95% CI: 0.02-0.30), while FDG-PET demonstrated a sensitivity of 0.38 (95% CI: 0.27-0.50) and specificity of 0.86 (95% CI: 0.31-0.99), with an area under the curve of 0.40 (95% CI: 0.36-0.44), an LR+ of 2.7 (95% CI: 0.3-27.8), and an LR- of 0.72 (95% CI: 0.47-1.11). Target-to-background ratios of either FDG or FET, however, allow distinction between low- and high-grade gliomas (P > .11).
For brain tumor diagnosis, FET-PET performed much better than FDG and should be preferred when assessing a new isolated brain tumor. For glioma grading, however, both tracers showed similar performances.

Keywords
Brain Neoplasms/classification, Brain Neoplasms/diagnostic imaging, Brain Neoplasms/pathology, Fluorodeoxyglucose F18, Glioma/diagnostic imaging, Glioma/pathology, Humans, Neoplasm Grading, Positron-Emission Tomography/methods, Radiopharmaceuticals, 18F-fluoro-deoxy-glucose, 18F-fluoro-ethyl-tyrosine, PET, brain tumor, meta-analysis
Pubmed
Web of science
Open Access
Yes
Create date
11/08/2015 14:36
Last modification date
02/09/2019 11:35
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