PPAR gamma: ally and foe in bone metabolism.

Wahli, W.

doi:10.1016/j.cmet.2008.02.005

PPAR gamma: ally and foe in bone metabolism.

Details

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Serval ID

serval:BIB_8FFE2B0EC4D7

Type

Article: article from journal or magazin.

Publication sub-type

Letter (letter): Communication to the publisher.

Collection

Publications

Institution

UNIL/CHUV

Title

PPAR gamma: ally and foe in bone metabolism.

Journal

Cell Metabolism

Author(s)

Wahli W.

ISSN

1550-4131[print]

Publication state

Published

Issued date

2008

Volume

Number

Pages

188-190

Language

english

Abstract

Bone homeostasis is a well-balanced process that is largely dependent on the contribution of both bone-forming osteoblasts and bone-resorbing osteoclasts. A new study (Wan et al., 2007) suggests a previously unsuspected role for the transcription factor PPARgamma in promoting bone progenitors to the osteoclastic lineage.

Keywords

Animals, Bone Remodeling/drug effects, Bone Resorption/metabolism, Cell Differentiation, Cell Lineage, Hematopoietic Stem Cells/metabolism, Humans, Mice, Mice, Knockout, NF-kappa B/metabolism, Osteoblasts/drug effects, Osteoblasts/metabolism, Osteoclasts/drug effects, Osteoclasts/metabolism, Osteopetrosis/metabolism, PPAR gamma/agonists, PPAR gamma/genetics, Proto-Oncogene Proteins c-fos/metabolism, Signal Transduction/drug effects, Thiazolidinediones/pharmacology

OAI-PMH

oai:serval.unil.ch:BIB_8FFE2B0EC4D7

DOI

10.1016/j.cmet.2008.02.005

Pubmed

18316021

Web of science

000253727300002

Open Access

Yes

Create date

29/01/2009 22:14