La rate: entre mystères et découvertes [The spleen: between mysteries and discoveries]

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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_82B7AC9B61E9
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
La rate: entre mystères et découvertes [The spleen: between mysteries and discoveries]
Journal
Revue medicale suisse
Author(s)
Leuenberger M., Sartori C.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
03/11/2010
Peer-reviewed
Oui
Volume
6
Number
269
Pages
2080-2082,2084-2085
Language
french
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Mainly because it is possible to live without it, the spleen has always been considered a secondary and mysterious organ. However, recent observations have revealed new unsuspected functions for this organ whose patho-physiological importance should be reconsidered. Much less known than the hypersplenism, the hyposplenism corresponds historically to the loss or the insufficiency of the two principal functions of spleen: the filtration of faded or senescent elements from the blood and the fight against infections. In this article, after a short recall of the physiological functions of spleen, three innovations relating to hyposplenism will be explored: the vascular complications, the loss of the splenic pool of regenerating monocytes and the loss of the splenic pool of pluripotent mesenchymal stem cell.
Keywords
Algorithms, Atherosclerosis/physiopathology, Humans, Mesenchymal Stem Cells, Monocytes/metabolism, Phagocytosis, Risk Factors, Spleen/blood supply, Spleen/physiology, Spleen/physiopathology, Splenic Diseases/blood, Splenic Diseases/complications, Splenic Diseases/diagnosis, Splenic Diseases/physiopathology, Thromboembolism/physiopathology
Pubmed
Create date
18/03/2011 10:51
Last modification date
18/04/2025 7:14
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