Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents.

Details

Ressource 1Download: BIB_7CEBEFE6EE3E.P001.pdf (799.91 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_7CEBEFE6EE3E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents.
Journal
Magnetic Resonance in Medicine
Author(s)
van Heeswijk R.B., Uffmann K., Comment A., Kurdzesau F., Perazzolo C., Cudalbu C., Jannin S., Konter J.A., Hautle P., van den Brandt B., Navon G., van der Klink J.J., Gruetter R.
ISSN
1522-2594 (Electronic)
ISSN-L
0740-3194
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
61
Number
6
Pages
1489-1493
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Lithium is widely used in psychotherapy. The (6)Li isotope has a long intrinsic longitudinal relaxation time T(1) on the order of minutes, making it an ideal candidate for hyperpolarization experiments. In the present study we demonstrated that lithium-6 can be readily hyperpolarized within 30 min, while retaining a long polarization decay time on the order of a minute. We used the intrinsically long relaxation time for the detection of 500 nM contrast agent in vitro. Hyperpolarized lithium-6 was administered to the rat and its signal retained a decay time on the order of 70 sec in vivo. Localization experiments imply that the lithium signal originated from within the brain and that it was detectable up to 5 min after administration. We conclude that the detection of submicromolar contrast agents using hyperpolarized NMR nuclei such as (6)Li may provide a novel avenue for molecular imaging.
Keywords
Animals, Brain/metabolism, Contrast Media/analysis, Contrast Media/pharmacokinetics, Isotopes/diagnostic use, Isotopes/pharmacokinetics, Lithium/diagnostic use, Lithium/pharmacokinetics, Magnetic Resonance Spectroscopy/methods, Male, Metabolic Clearance Rate, Molecular Probe Techniques, Molecular Probes, Nanostructures/chemistry, Radiopharmaceuticals/diagnostic use, Radiopharmaceuticals/pharmacokinetics, Rats, Rats, Sprague-Dawley
Pubmed
Web of science
Open Access
Yes
Create date
04/08/2010 15:28
Last modification date
20/08/2019 14:38
Usage data