Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents.
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Version: author
State: Public
Version: author
Serval ID
serval:BIB_7CEBEFE6EE3E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents.
Journal
Magnetic Resonance in Medicine
ISSN
1522-2594 (Electronic)
ISSN-L
0740-3194
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
61
Number
6
Pages
1489-1493
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Lithium is widely used in psychotherapy. The (6)Li isotope has a long intrinsic longitudinal relaxation time T(1) on the order of minutes, making it an ideal candidate for hyperpolarization experiments. In the present study we demonstrated that lithium-6 can be readily hyperpolarized within 30 min, while retaining a long polarization decay time on the order of a minute. We used the intrinsically long relaxation time for the detection of 500 nM contrast agent in vitro. Hyperpolarized lithium-6 was administered to the rat and its signal retained a decay time on the order of 70 sec in vivo. Localization experiments imply that the lithium signal originated from within the brain and that it was detectable up to 5 min after administration. We conclude that the detection of submicromolar contrast agents using hyperpolarized NMR nuclei such as (6)Li may provide a novel avenue for molecular imaging.
Keywords
Animals, Brain/metabolism, Contrast Media/analysis, Contrast Media/pharmacokinetics, Isotopes/diagnostic use, Isotopes/pharmacokinetics, Lithium/diagnostic use, Lithium/pharmacokinetics, Magnetic Resonance Spectroscopy/methods, Male, Metabolic Clearance Rate, Molecular Probe Techniques, Molecular Probes, Nanostructures/chemistry, Radiopharmaceuticals/diagnostic use, Radiopharmaceuticals/pharmacokinetics, Rats, Rats, Sprague-Dawley
Pubmed
Web of science
Open Access
Yes
Create date
04/08/2010 16:28
Last modification date
20/08/2019 15:38