Experimental evolution of slowed cognitive aging in Drosophila melanogaster.

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State: Public
Version: Final published version
Serval ID
serval:BIB_7CE03F32298D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Experimental evolution of slowed cognitive aging in Drosophila melanogaster.
Journal
Evolution
Author(s)
Zwoinska M.K., Maklakov A.A., Kawecki T.J., Hollis B.
ISSN
1558-5646 (Electronic)
ISSN-L
0014-3820
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
71
Number
3
Pages
662-670
Language
english
Abstract
Reproductive output and cognitive performance decline in parallel during aging, but it is unknown whether this reflects a shared genetic architecture or merely the declining force of natural selection acting independently on both traits. We used experimental evolution in Drosophila melanogaster to test for the presence of genetic variation for slowed cognitive aging, and assess its independence from that responsible for other traits' decline with age. Replicate experimental populations experienced either joint selection on learning and reproduction at old age (Old + Learning), selection on late-life reproduction alone (Old), or a standard two-week culture regime (Young). Within 20 generations, the Old + Learning populations evolved a slower decline in learning with age than both the Old and Young populations, revealing genetic variation for cognitive aging. We found little evidence for a genetic correlation between cognitive and demographic aging: although the Old + Learning populations tended to show higher late-life fecundity than Old populations, they did not live longer. Likewise, selection for late reproduction alone did not result in improved late-life learning. Our results demonstrate that Drosophila harbor genetic variation for cognitive aging that is largely independent from genetic variation for demographic aging and suggest that these two aspects of aging may not necessarily follow the same trajectories.

Pubmed
Web of science
Open Access
Yes
Create date
29/12/2016 9:29
Last modification date
20/08/2019 15:38
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