Complex genetic patterns in human arise from a simple range-expansion model over continental landmasses.

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Serval ID
serval:BIB_77ADA568BCF2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Complex genetic patterns in human arise from a simple range-expansion model over continental landmasses.
Journal
PLoS One
Author(s)
Kanitz R., Guillot E.G., Antoniazza S., Neuenschwander S., Goudet J.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
13
Number
2
Pages
e0192460
Language
english
Abstract
Although it is generally accepted that geography is a major factor shaping human genetic differentiation, it is still disputed how much of this differentiation is a result of a simple process of isolation-by-distance, and if there are factors generating distinct clusters of genetic similarity. We address this question using a geographically explicit simulation framework coupled with an Approximate Bayesian Computation approach. Based on six simple summary statistics only, we estimated the most probable demographic parameters that shaped modern human evolution under an isolation by distance scenario, and found these were the following: an initial population in East Africa spread and grew from 4000 individuals to 5.7 million in about 132 000 years. Subsequent simulations with these estimates followed by cluster analyses produced results nearly identical to those obtained in real data. Thus, a simple diffusion model from East Africa explains a large portion of the genetic diversity patterns observed in modern humans. We argue that a model of isolation by distance along the continental landmasses might be the relevant null model to use when investigating selective effects in humans and probably many other species.

Keywords
General Biochemistry, Genetics and Molecular Biology, General Agricultural and Biological Sciences, General Medicine
Pubmed
Web of science
Open Access
Yes
Create date
26/02/2018 10:00
Last modification date
20/08/2019 15:34
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