Innate and adaptive effects of inflammasomes on T cell responses.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_740A0D42CE97
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Innate and adaptive effects of inflammasomes on T cell responses.
Journal
Current Opinion in Immunology
Author(s)
Dostert C., Ludigs K., Guarda G.
ISSN
1879-0372 (Electronic)
ISSN-L
0952-7915
Publication state
Published
Issued date
2013
Volume
25
Number
3
Pages
359-365
Language
english
Abstract
Inflammasomes are protein complexes that form in response to pathogen-derived or host-derived stress signals. Their activation leads to the production of inflammatory cytokines and promotes a pyrogenic cell death process. The massive release of inflammatory mediators that follows inflammasome activation is a key event in alarming innate immune cells. Growing evidence also highlights the role of inflammasome-dependent cytokines in shaping the adaptive immune response, as exemplified by the capacity of IL-1β to support Th17 responses, or by the finding that IL-18 evokes antigen-independent IFN-γ secretion by memory CD8(+) T cells. A deeper understanding of these mechanisms and on how to manipulate this powerful inflammatory system therefore represents an important step forward in the development of improved vaccine strategies.
Pubmed
Web of science
Create date
13/12/2013 17:46
Last modification date
20/08/2019 15:31
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