Mammalian neural stem-cell renewal: nature versus nurture

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Serval ID
serval:BIB_727A94741965
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Mammalian neural stem-cell renewal: nature versus nurture
Journal
Molecular Neurobiology
Author(s)
Arsenijevic  Y.
ISSN
0893-7648 (Print)
Publication state
Published
Issued date
02/2003
Volume
27
Number
1
Pages
73-98
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Feb
Abstract
Recent data show that the final events of mammalian brain organogenesis may depend in part on the direct control of neural stem cell (NSC) proliferation and survival. Environmental and intrinsic factors play a role throughout development and during adulthood to regulate NSC proliferation. The NSCs acquire new competences throughout development, including adulthood, and this change in competence is region-specific. The factors controlling NSC survival, undifferentiated state, proliferation, and cell-cycle number are beginning to be identified, but the links between them remain unclear. However, current knowledge should help to formulate an understanding of how a stem cell can generate a new stem cell.
Keywords
Animals Brain/*cytology/*embryology/metabolism Cell Differentiation/*physiology Cell Division/*physiology Cell Lineage/physiology Gene Expression Regulation, Developmental/physiology Humans Nerve Growth Factors/metabolism Neuroglia/cytology/physiology Neurons/*cytology/metabolism Stem Cells/*cytology/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 12:31
Last modification date
01/10/2019 6:18
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