T-cell repertoire analysis and metrics of diversity and clonality.

Details

Serval ID
serval:BIB_598F3EDCA20B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
T-cell repertoire analysis and metrics of diversity and clonality.
Journal
Current opinion in biotechnology
Author(s)
Chiffelle J., Genolet R., Perez M.A., Coukos G., Zoete V., Harari A.
ISSN
1879-0429 (Electronic)
ISSN-L
0958-1669
Publication state
Published
Issued date
10/2020
Peer-reviewed
Oui
Volume
65
Pages
284-295
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The recent developments of high-throughput bulk and single-cell sequencing technologies accelerated the understanding of the complexity of immune repertoire dynamics combined to transcriptomics. Also, profiling of cellular repertoires in health or disease requires statistical metrics to capture clonal diversity characterized by clones frequency, repertoire richness and convergence. Here we present the common technologies of bulk and single-cell sequencing of T-cell receptors (TCRs), discuss current knowledge regarding computational tools clustering and predicting specificity of TCR repertoires based on shared structural motifs and review main indices for repertoire diversity and convergence analyses. These tools represent potential biomarkers to decipher the fitness of immune repertoires in diseased or treated patients but also the presages and promises of computational approaches to revolutionize personalized immunotherapy.
Pubmed
Web of science
Open Access
Yes
Create date
14/09/2020 9:40
Last modification date
06/01/2021 7:25
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