The association of aldosterone with obesity-related hypertension and the metabolic syndrome.

Details

Serval ID
serval:BIB_5445B36DACCA
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The association of aldosterone with obesity-related hypertension and the metabolic syndrome.
Journal
Seminars in nephrology
Author(s)
Vogt B., Bochud M., Burnier M.
ISSN
0270-9295
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
27
Number
5
Pages
529-537
Language
english
Notes
Publication types: Journal Article ; Review - Publication Status: ppublish
Abstract
Overweight and obesity are associated with arterial hypertension. Given the large increase in the obesity prevalence worldwide, the number of obese patients with hypertension is likely to increase substantially in the near future. Overweight and obese patients are exposed to an important metabolic and cardiovascular risk. The understanding of the mechanisms linking obesity to hypertension is important for specific prevention and therapy in this population. There is some evidence that obesity is associated with an increased aldosterone level. To date, 2 mechanisms may explain the interaction of fat tissue with the renin-angiotensin-aldosterone system, and therefore explain, in part, obesity-related hypertension. First, human adipose tissue produces several components of the renin-angiotensin-aldosterone system, mainly adipose tissue-derived angiotensinogen. Second, increased fatty acid production in the obese patient, especially nonesterified fatty acids, might stimulate aldosterone production, independent of renin. A better understanding of these mechanisms might have implications for the management of hypertension in overweight and obese patients. Because aldosterone also is associated with blood glucose and blood lipids, selective aldosterone blockade may represent a particularly attractive therapeutic strategy in obese patients with a clustering of cardiovascular risk factors.
Keywords
Adipose Tissue, Aldosterone, Animals, Blood Pressure, Humans, Hypertension, Metabolic Syndrome X, Obesity, Prognosis, Risk Factors
Pubmed
Web of science
Create date
25/01/2008 13:03
Last modification date
20/08/2019 14:09
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