The association of aldosterone with obesity-related hypertension and the metabolic syndrome.

Détails

ID Serval
serval:BIB_5445B36DACCA
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The association of aldosterone with obesity-related hypertension and the metabolic syndrome.
Périodique
Seminars in nephrology
Auteur(s)
Vogt B., Bochud M., Burnier M.
ISSN
0270-9295
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
27
Numéro
5
Pages
529-537
Langue
anglais
Notes
Publication types: Journal Article ; Review - Publication Status: ppublish
Résumé
Overweight and obesity are associated with arterial hypertension. Given the large increase in the obesity prevalence worldwide, the number of obese patients with hypertension is likely to increase substantially in the near future. Overweight and obese patients are exposed to an important metabolic and cardiovascular risk. The understanding of the mechanisms linking obesity to hypertension is important for specific prevention and therapy in this population. There is some evidence that obesity is associated with an increased aldosterone level. To date, 2 mechanisms may explain the interaction of fat tissue with the renin-angiotensin-aldosterone system, and therefore explain, in part, obesity-related hypertension. First, human adipose tissue produces several components of the renin-angiotensin-aldosterone system, mainly adipose tissue-derived angiotensinogen. Second, increased fatty acid production in the obese patient, especially nonesterified fatty acids, might stimulate aldosterone production, independent of renin. A better understanding of these mechanisms might have implications for the management of hypertension in overweight and obese patients. Because aldosterone also is associated with blood glucose and blood lipids, selective aldosterone blockade may represent a particularly attractive therapeutic strategy in obese patients with a clustering of cardiovascular risk factors.
Mots-clé
Adipose Tissue, Aldosterone, Animals, Blood Pressure, Humans, Hypertension, Metabolic Syndrome X, Obesity, Prognosis, Risk Factors
Pubmed
Web of science
Création de la notice
25/01/2008 13:03
Dernière modification de la notice
20/08/2019 14:09
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