Transposition of Tn1213 Encoding the PER-1 Extended-Spectrum β-Lactamase.

Details

Serval ID
serval:BIB_3F90F8AA669F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Transposition of Tn1213 Encoding the PER-1 Extended-Spectrum β-Lactamase.
Journal
Antimicrobial agents and chemotherapy
Author(s)
Mancini S., Poirel L., Kieffer N., Nordmann P.
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Publication state
Published
Issued date
03/2018
Peer-reviewed
Oui
Volume
62
Number
3
Pages
e02453-17
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
PER-1 is an extended-spectrum β-lactamase that is encoded by a gene located in composite transposon Tn1213 made by two distinct insertion sequences, namely, ISPa12 and ISPa13. In vitro mobilization performed in Escherichia coli shows that Tn1213 is functional and is able to mobilize the bla <sub>PER-1</sub> gene, although at a very low frequency (ca. 1 × 10 <sup>-9</sup> ).
Keywords
Anti-Bacterial Agents/pharmacology, Base Sequence, Chloramphenicol/pharmacology, DNA Transposable Elements, Drug Resistance, Multiple, Bacterial/genetics, Escherichia coli/drug effects, Escherichia coli/enzymology, Escherichia coli/genetics, Escherichia coli/growth & development, Gene Expression Regulation, Bacterial, Gene Transfer, Horizontal, Microbial Sensitivity Tests, Plasmids/chemistry, Plasmids/metabolism, beta-Lactamases/genetics, beta-Lactamases/metabolism, PER-1, extended-spectrum beta-lactamase, transposition
Pubmed
Web of science
Open Access
Yes
Create date
22/01/2018 11:09
Last modification date
20/08/2019 13:36
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