Transposition of Tn1213 Encoding the PER-1 Extended-Spectrum β-Lactamase.

Mancini, S.; Poirel, L.; Kieffer, N.; Nordmann, P.

doi:10.1128/AAC.02453-17

Transposition of Tn1213 Encoding the PER-1 Extended-Spectrum β-Lactamase.

Détails

Demande d'une copie

ID Serval

serval:BIB_3F90F8AA669F

Type

Article: article d'un périodique ou d'un magazine.

Collection

Publications

Institution

UNIL/CHUV

Titre

Transposition of Tn1213 Encoding the PER-1 Extended-Spectrum β-Lactamase.

Périodique

Antimicrobial agents and chemotherapy

Auteur⸱e⸱s

Mancini S., Poirel L., Kieffer N., Nordmann P.

ISSN

1098-6596 (Electronic)

ISSN-L

0066-4804

Statut éditorial

Publié

Date de publication

03/2018

Peer-reviewed

Oui

Volume

Numéro

Pages

e02453-17

Langue

anglais

Notes

Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish

Résumé

PER-1 is an extended-spectrum β-lactamase that is encoded by a gene located in composite transposon Tn1213 made by two distinct insertion sequences, namely, ISPa12 and ISPa13. In vitro mobilization performed in Escherichia coli shows that Tn1213 is functional and is able to mobilize the bla <sub>PER-1</sub> gene, although at a very low frequency (ca. 1 × 10 <sup>-9</sup> ).

Mots-clé

Anti-Bacterial Agents/pharmacology, Base Sequence, Chloramphenicol/pharmacology, DNA Transposable Elements, Drug Resistance, Multiple, Bacterial/genetics, Escherichia coli/drug effects, Escherichia coli/enzymology, Escherichia coli/genetics, Escherichia coli/growth & development, Gene Expression Regulation, Bacterial, Gene Transfer, Horizontal, Microbial Sensitivity Tests, Plasmids/chemistry, Plasmids/metabolism, beta-Lactamases/genetics, beta-Lactamases/metabolism, PER-1, extended-spectrum beta-lactamase, transposition

OAI-PMH

oai:serval.unil.ch:BIB_3F90F8AA669F

DOI

10.1128/AAC.02453-17

Pubmed

29311060

Web of science

000427121800041

Open Access

Oui

Création de la notice

22/01/2018 12:09