Transposition of Tn1213 Encoding the PER-1 Extended-Spectrum β-Lactamase.

Mancini, S.; Poirel, L.; Kieffer, N.; Nordmann, P.

doi:10.1128/AAC.02453-17

Transposition of Tn1213 Encoding the PER-1 Extended-Spectrum β-Lactamase.

Details

Request a copy

Serval ID

serval:BIB_3F90F8AA669F

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Transposition of Tn1213 Encoding the PER-1 Extended-Spectrum β-Lactamase.

Journal

Antimicrobial agents and chemotherapy

Author(s)

Mancini S., Poirel L., Kieffer N., Nordmann P.

ISSN

1098-6596 (Electronic)

ISSN-L

0066-4804

Publication state

Published

Issued date

03/2018

Peer-reviewed

Oui

Volume

Number

Pages

e02453-17

Language

english

Notes

Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish

Abstract

PER-1 is an extended-spectrum β-lactamase that is encoded by a gene located in composite transposon Tn1213 made by two distinct insertion sequences, namely, ISPa12 and ISPa13. In vitro mobilization performed in Escherichia coli shows that Tn1213 is functional and is able to mobilize the bla <sub>PER-1</sub> gene, although at a very low frequency (ca. 1 × 10 <sup>-9</sup> ).

Keywords

Anti-Bacterial Agents/pharmacology, Base Sequence, Chloramphenicol/pharmacology, DNA Transposable Elements, Drug Resistance, Multiple, Bacterial/genetics, Escherichia coli/drug effects, Escherichia coli/enzymology, Escherichia coli/genetics, Escherichia coli/growth & development, Gene Expression Regulation, Bacterial, Gene Transfer, Horizontal, Microbial Sensitivity Tests, Plasmids/chemistry, Plasmids/metabolism, beta-Lactamases/genetics, beta-Lactamases/metabolism, PER-1, extended-spectrum beta-lactamase, transposition

OAI-PMH

oai:serval.unil.ch:BIB_3F90F8AA669F

DOI

10.1128/AAC.02453-17

Pubmed

29311060

Web of science

000427121800041

Open Access

Yes

Create date

22/01/2018 12:09