Reassessment of recommended imipenem doses in febrile neutropenic patients with hematological malignancies.

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Serval ID
serval:BIB_3C81678B0325
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Reassessment of recommended imipenem doses in febrile neutropenic patients with hematological malignancies.
Journal
Antimicrobial Agents and Chemotherapy
Author(s)
Lamoth F., Buclin T., Csajka C., Pascual A., Calandra T., Marchetti O.
ISSN
1098-6596
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
53
Number
2
Pages
785-787
Language
english
Abstract
Imipenem plasma concentrations were analyzed in 57 febrile neutropenic patients using the NONMEM program. The recommended 2-g/day regimen achieved coverage of the most common bacteria (MIC(90) = 1 mg/liter) during the whole dosing interval in only 53% of patients. This goal was achieved in 90% of patients with 3 g/day.
OAI-PMH
oai:serval.unil.ch:BIB_3C81678B0325
DOI
10.1128/AAC.00891-08
Pubmed
19047655
Web of science
000262646500057
Open Access
Yes
Create date
26/02/2009 17:28
Last modification date
20/08/2019 14:32
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