MAR-Mediated Dystrophin Expression in Mesoangioblasts for Duchenne Muscular Dystrophy Cell Therapy

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Serval ID
serval:BIB_37D3FB4E9965
Type
Article: article from journal or magazin.
Collection
Publications
Title
MAR-Mediated Dystrophin Expression in Mesoangioblasts for Duchenne Muscular Dystrophy Cell Therapy
Journal
Molecular Biology
Author(s)
van Zwieten R.W., Iyer P., Majocchi S., Dusserre Y., Puttini S., Tedesco F.S., Cossu G, Mermod N.
ISSN
2168-9547
Publication state
Published
Issued date
2015
Volume
04
Number
03
Pages
134
Language
english
Abstract
A cornerstone of autologous cell therapy for Duchenne muscular dystrophy is the engineering of suitable cells to express dystrophin in a stable fashion upon differentiation to muscle fibers. Most viral transduction methods are typically restricted to the expression of truncated recombinant dystrophin derivatives and by the risk of insertional mutagenesis, while non-viral vectors often suffer from inefficient transfer, expression and/or silencing.
Open Access
Yes
Create date
31/01/2017 11:09
Last modification date
20/08/2019 13:26
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