Major histocompatibility complex-linked social signalling affects female fertility.

Details

Ressource 1Download: Burger et al. Proc B 2017.pdf (4062.10 [Ko])
State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_30EE7C2B84F4
Type
Article: article from journal or magazin.
Collection
Publications
Title
Major histocompatibility complex-linked social signalling affects female fertility.
Journal
Proceedings. Biological sciences
Author(s)
Burger D., Thomas S., Aepli H., Dreyer M., Fabre G., Marti E., Sieme H., Robinson M.R., Wedekind C.
ISSN
1471-2954 (Electronic)
ISSN-L
0962-8452
Publication state
Published
Issued date
06/12/2017
Peer-reviewed
Oui
Volume
284
Number
1868
Pages
20171824
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Genes of the major histocompatibility complex (MHC) have been shown to influence social signalling and mate preferences in many species, including humans. First observations suggest that MHC signalling may also affect female fertility. To test this hypothesis, we exposed 191 female horses ( <i>Equus caballus</i> ) to either an MHC-similar or an MHC-dissimilar stimulus male around the time of ovulation and conception. A within-subject experimental design controlled for non-MHC-linked male characteristics, and instrumental insemination with semen of other males ( <i>n</i> = 106) controlled for potential confounding effects of semen or embryo characteristics. We found that females were more likely to become pregnant if exposed to an MHC-dissimilar than to an MHC-similar male, while overall genetic distance to the stimulus males (based on microsatellite markers on 20 chromosomes) had no effect. Our results demonstrate that early pregnancy failures can be due to maternal life-history decisions (cryptic female choice) influenced by MHC-linked social signalling.
Keywords
Animals, Female, Fertility, Horses/physiology, Major Histocompatibility Complex, Mating Preference, Animal, Reproduction, cryptic female choice, female reproductive strategy, fertility, major histocompatibility complex, mammals, sexual selection
Pubmed
Web of science
Create date
02/11/2017 15:42
Last modification date
20/08/2019 14:15
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