Antifungal resistance and new strategies to control fungal infections.

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Ressource 1Download: BIB_24739707241E.P001.pdf (1978.22 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_24739707241E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Antifungal resistance and new strategies to control fungal infections.
Journal
International Journal of Microbiology
Author(s)
Vandeputte P., Ferrari S., Coste A.T.
ISSN
1687-9198 (Electronic)
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
2012
Number
713687
Pages
1-26
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish. PDF type: review article
Abstract
Despite improvement of antifungal therapies over the last 30 years, the phenomenon of antifungal resistance is still of major concern in clinical practice. In the last 10 years the molecular mechanisms underlying this phenomenon were extensively unraveled. In this paper, after a brief overview of currently available antifungals, molecular mechanisms of antifungal resistance will be detailed. It appears that major mechanisms of resistance are essential due to the deregulation of antifungal resistance effector genes. This deregulation is a consequence of point mutations occurring in transcriptional regulators of these effector genes. Resistance can also follow the emergence of point mutations directly in the genes coding antifungal targets. In addition we further describe new strategies currently undertaken to discover alternative therapy targets and antifungals. Identification of new antifungals is essentially achieved by the screening of natural or synthetic chemical compound collections. Discovery of new putative antifungal targets is performed through genome-wide approaches for a better understanding of the human pathogenic fungi biology.
Pubmed
Open Access
Yes
Create date
18/01/2013 10:51
Last modification date
20/08/2019 13:02
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