Macrophage migration inhibitory factor and host innate immune defenses against bacterial sepsis.

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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_19D02A04C9E2
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Macrophage migration inhibitory factor and host innate immune defenses against bacterial sepsis.
Journal
The Journal of infectious diseases
Author(s)
Calandra T., Froidevaux C., Martin C., Roger T.
ISSN
0022-1899
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
187 Suppl 2
Pages
S385-90
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
Macrophages are essential effector cells of innate immunity that play a pivotal role in the recognition and elimination of invasive microorganisms. Mediators released by activated macrophages orchestrate innate and adaptive immune host responses. The cytokine macrophage migration inhibitory factor (MIF) is an integral mediator of the innate immune system. Monocytes and macrophages constitutively express large amounts of MIF, which is rapidly released after exposure to bacterial toxins and cytokines. MIF exerts potent proinflammatory activities and is an important cytokine of septic shock. Recent investigations of the mechanisms by which MIF regulates innate immune responses to endotoxin and gram-negative bacteria indicate that MIF acts by modulating the expression of Toll-like receptor 4, the signal-transducing molecule of the lipopolysaccharide receptor complex. Given its role in innate immune responses to bacterial infections, MIF is a novel target for therapeutic intervention in patients with septic shock.
Keywords
Animals, Bacterial Infections, Bacterial Toxins, Gene Expression Regulation, Humans, Immunity, Innate, Inflammation, Macrophage Migration-Inhibitory Factors, Macrophages, Sepsis
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 14:35
Last modification date
25/09/2019 7:08
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