Acquired von Willebrand syndrome in a myeloproliferative disorder. Case 6.

Details

Serval ID
serval:BIB_15730D5C1EC9
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Acquired von Willebrand syndrome in a myeloproliferative disorder. Case 6.
Journal
Hämostaseologie
Author(s)
Baud P., Tobler A., Lämmle B., Alberio L.
ISSN
0720-9355 (Print)
ISSN-L
0720-9355
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
23
Number
3
Pages
121-124
Language
english
Notes
Publication types: Case Reports ; Journal Article Publication Status: ppublish
Abstract
We present a woman (age: 57 years) with an excessive bleeding episode under acetylsalicylic acid after bone marrow puncture due to an acquired von Willebrand syndrome (avWS) in the context of a myeloproliferative disorder. The laboratory features showed a high platelet concentration and a qualitative defect of von Willebrand factor (vWF) with a low normal vWF ristocetin cofactor activity, a normal vWF antigen and a decrease of the larger vWF multimers in plasma. The exact mechanism of avWS is still incompletely resolved. Myeloproliferative diseases are one of several underlying disorders that may cause avWS. The diagnosis of the underlying disease is important because its treatment may lead to an improvement of the vWF abnormality. For symptomatic treatment of bleeding, desmopressin, vWF concentrate infusion, intravenous immunoglobulin and/or fibrinolysis inhibitors can be tried.
Keywords
Anti-Inflammatory Agents, Non-Steroidal/adverse effects, Aspirin/adverse effects, Humans, Male, Middle Aged, Myeloproliferative Disorders/blood, Myeloproliferative Disorders/drug therapy, von Willebrand Diseases/chemically induced, von Willebrand Factor/genetics
Pubmed
Create date
10/02/2015 11:26
Last modification date
20/08/2019 12:44
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