MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the Eleonora's falcon.

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Version: Final published version
Serval ID
serval:BIB_034376670B5D
Type
Article: article from journal or magazin.
Collection
Publications
Title
MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the Eleonora's falcon.
Journal
Journal of Evolutionary Biology
Author(s)
Gangoso L., Grande J.M., Ducrest A.L., Figuerola J., Bortolotti G.R., Andrés J.A., Roulin A.
ISSN
1420-9101 (Electronic)
ISSN-L
1010-061X
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
24
Number
9
Pages
2055-2063
Language
english
Abstract
Colour polymorphism in vertebrates is usually under genetic control and may be associated with variation in physiological traits. The melanocortin 1 receptor (Mc1r) has been involved repeatedly in melanin-based pigmentation but it was thought to have few other physiological effects. However, recent pharmacological studies suggest that MC1R could regulate the aspects of immunity. We investigated whether variation at Mc1r underpins plumage colouration in the Eleonora's falcon. We also examined whether nestlings of the different morphs differed in their inflammatory response induced by phytohemagglutinin (PHA). Variation in colouration was due to a deletion of four amino acids at the Mc1r gene. Cellular immune response was morph specific. In males, but not in females, dark nestling mounted a lower PHA response than pale ones. Although correlative, our results raise the neglected possibility that MC1R has pleiotropic effects, suggesting a potential role of immune capacity and pathogen pressure on the maintenance of colour polymorphism in this species.
Keywords
Animals, Animals, Newborn, Body Weight, Falconiformes/genetics, Falconiformes/immunology, Female, Genotype, Immunity, Cellular, Male, Phenotype, Phytohemagglutinins, Pigmentation/genetics, Pigmentation/immunology, Receptor, Melanocortin, Type 1/genetics, Receptor, Melanocortin, Type 1/immunology, Sequence Deletion
Pubmed
Web of science
Open Access
Yes
Create date
22/05/2011 17:23
Last modification date
20/08/2019 13:25
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