Lack of association between ADH3 polymorphism, alcohol intake, risk factors and carotid intima-media thickness
Details
Serval ID
serval:BIB_FFFD7938BEF9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lack of association between ADH3 polymorphism, alcohol intake, risk factors and carotid intima-media thickness
Journal
Atherosclerosis
ISSN
0021-9150 (Print)
ISSN-L
0021-9150
Publication state
Published
Issued date
2005
Volume
184
Number
2
Pages
397-403
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
OBJECTIVE: We assess the relationships between alcohol dehydrogenase 3 (ADH3) polymorphism, alcohol consumption and cardiovascular risk factor levels.
METHODS: In a representative population sample from Southwestern France (614 men, 567 women, age 49.7+/-8.5 years), alcohol intake was assessed by questionnaire.
RESULTS: Alcohol consumption was significantly related with higher levels of total and HDL cholesterol, triglycerides, apolipoprotein A-I in men and with higher levels of HDL cholesterol in women. Also, an inverse relationship between alcohol consumption and intima-media thickness was found in men. Conversely, in both genders, no differences were found between ADH3 genotypes regarding all cardiovascular risk factors studied and carotid intima-media thickness. Also, in both genders, no significant ADH3xalcohol interaction was found for all variables, and further adjustment on age, body mass index, educational level, smoking status or after excluding subjects on hypolipidemic or antihypertensive drug treatment did not change the results.
CONCLUSION: We found no interaction between the ADH3 polymorphism and alcohol intake on cardiovascular risk factor levels and atherosclerotic markers in Southwestern France.
METHODS: In a representative population sample from Southwestern France (614 men, 567 women, age 49.7+/-8.5 years), alcohol intake was assessed by questionnaire.
RESULTS: Alcohol consumption was significantly related with higher levels of total and HDL cholesterol, triglycerides, apolipoprotein A-I in men and with higher levels of HDL cholesterol in women. Also, an inverse relationship between alcohol consumption and intima-media thickness was found in men. Conversely, in both genders, no differences were found between ADH3 genotypes regarding all cardiovascular risk factors studied and carotid intima-media thickness. Also, in both genders, no significant ADH3xalcohol interaction was found for all variables, and further adjustment on age, body mass index, educational level, smoking status or after excluding subjects on hypolipidemic or antihypertensive drug treatment did not change the results.
CONCLUSION: We found no interaction between the ADH3 polymorphism and alcohol intake on cardiovascular risk factor levels and atherosclerotic markers in Southwestern France.
Keywords
Alcohol Dehydrogenase/genetics, Alcohol Dehydrogenase/metabolism, Alcohol Drinking/adverse effects, Alcohol Drinking/blood, Atherosclerosis/blood, Atherosclerosis/etiology, Atherosclerosis/ultrasonography, Carotid Artery, Common/ultrasonography, Cholesterol, HDL/blood, DNA/genetics, Tunica Intima/ultrasonography
Pubmed
Web of science
Create date
01/12/2016 16:01
Last modification date
20/08/2019 17:30
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