Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Progressive loss of speech output and orofacial dyspraxia associated with frontal lobe hypometabolism.
Journal of Neurology, Neurosurgery, and Psychiatry
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Three patients are described with slowly progressive loss of speech and dysarthria associated with orofacial dyspraxia, initially with intact written language, who subsequently developed more widespread cognitive abnormalities. Positron emission tomography (PET) revealed bifrontal hypometabolism in all of the patients, most marked in the inferior and lateral portions of both frontal lobes, with some extension into the parietal and temporal cortices in one case. These patients may represent a further example of focal progressive cortical degeneration.
Aged, Apraxias/diagnosis, Apraxias/physiopathology, Brain Damage, Chronic/diagnosis, Brain Damage, Chronic/physiopathology, Delirium, Dementia, Amnestic, Cognitive Disorders/diagnosis, Delirium, Dementia, Amnestic, Cognitive Disorders/physiopathology, Dysarthria/diagnosis, Dysarthria/physiopathology, Energy Metabolism/physiology, Female, Frontal Lobe/physiopathology, Humans, Intelligence/physiology, Male, Middle Aged, Nerve Degeneration/physiology, Neuropsychological Tests, Parietal Lobe/physiopathology, Speech Production Measurement, Temporal Lobe/physiopathology, Tomography, Emission-Computed, Tomography, X-Ray Computed, Verbal Behavior/physiology
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