Adjunctive dexamethasone and 30-day all-cause death after hospital admission in paediatric pneumococcal meningitis: a propensity score analysis.
Details
Serval ID
serval:BIB_FFF2B98E1571
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Adjunctive dexamethasone and 30-day all-cause death after hospital admission in paediatric pneumococcal meningitis: a propensity score analysis.
Journal
The Lancet. Child & adolescent health
Working group(s)
French Paediatric Meningitis Network, French Paediatric Meningitis, Network
Contributor(s)
Abadie V., Abdanne M., Abdelhadi M., Aberrane S., Ackermann S., Adam M.N., Adamon L., Adi G., Akitani S., Al Jazayri Z., Al Junaidi A., Al Mazini C., Alba-Sauviat C., Albertini M.T., Allia A., Allouche C., Amama H., Amara M., Amirault P., Amsallem D., Andre M., Andriantahina I., Anxionnat R., Arlet G., Armouche S., Astruc D., Auburtin B., Audry Degardin E., Autret F., Ayadi N., Ayaz-Bensultana N., Bachelier M.N., Baleine J., Balitalike J., Bandin O., Banegas D., Banerjee A., Baret M., Barnaud G., Baron-Joly S., Barrans A., Barrey C., Barsotti K., Barthez M.A., Baruteau R., Basmaci R., Bassil J., Battaglini P., Beaumier S., Bednarek N., Belgaid A., Belivier E., Bellulo S., Ben Said M., Benabdelmalek F., Benbih M., Benchekroun K., Benezech C., Bengrina M., Benmahammed A., Benmonsour L., Benmoulai I., Benoist G., Benoit C., Bensaid P., Benseddik Z., Berche P., Beretta-Salaun G., Bergounioux J., Berneau P., Berterottiere D., Bertrou A., Biessy H., Bilger M., Billaud N., Billion P., Bina A., Bineau P., Biran V., Blacnkaert C., Blanc P., Blanc S., Blasquez A., Blondel E., Blondin G., Blot N., Boileau P., Boize P., Bolot P., Bonacorsi S., Bongo Boina R., Bonnin M., Boquet P., Bosdure E., Bosi C., Bost-Bru C., Boukezia N., Boukhris S., Boulard S., Boulfoul D., Boumecid H., Bour J., Bourennane M., Bourgeois-Nicolaos N., Boussadia H., Boussard N., Boussicault G., Boutry M., Bouvy E., Boyer S., Branger C., Brechet C., Bresson V., Breuil J., Briennon C., Brieu N., Brisset S., Brocard A., Broenen E., Brouard J., Bruna A.L., Bucher J., Bueno B., Buisson-Touati C., Butin M., Cabaret B., Cadot L., Caillon J., Callamand P., Cambon D., Cambonie G., Canis F., Canzi A.M., Capdeville X, Carbajal R., Carbonnelle B., Carre-Cavellier J., Carrer A., Carriere C., Carroger G., Cartier-Riviere B., Cascarigny F., Casha P., Castelnau P., Cattoen C., Cattoir V., Caurier B., Cavalier A., Cazau C., Cecille A., Celton G., Chaabane A., Chabrol B., Chacé A., Chahine J., Chaix Y., Chalumeau M., Chalvon Demersay A., Chamouilli J.M., Champion V., Chantelat P., Chantreuil J., Chaplain C., Charachon S., Charbonneau A., Chardon H., Charpentier S., Charreton C., Chellun P., Chenel C., Cheron M., Cheuret E., Chevallier B., Chevrel J., Chevret L., Chognot D., Chomienne F., Chosidow A., Chrisment D., Ciupek C., Clair P., Claris O., Clavel C., Cochat P., Coche D., Coinde E., Colombani J.C., Combe J.C., Cordier A.M., Cormier P., Corniau F., Costa G., Costa Y., Cottin J., Coumenges P., Courcol R., Courdavault L., Courouble G., Courtade H., Coutable A., Craiu I., Crepet F., DA E., Daire-Chabanon I., Dalmon F., Danan C., Danekova N., Danjean-Deguin M.P., Danquigny A.L., Dao-Dubremetz A., Daoud P., Daoudi F., Darai E., Darnaud C., Darras J.P., Dassieu G., Dauger S., DE Barbentane M.C., DE Champs C., DE Decker L., DE Montclos H., DE Pontual L., Debriel D., Decoster A., Degas V., Delacour T., Delafay M., Delamare C., Delaporte G., Delarbre J.M., Delavelle C., Delbeke E., Delesalle S., Deligne D., Delimele M., Delorme D., Deluca D., Delvart C., Demachy M.C., Demarcq M.J., Demarque N., Demayer N., Demay-Legros G., Demonchy D., Desbois D., Deschamps N., Desfrere L., Deshayes DE Cambronne R., Desse B., Dessein R., Dessioux E., Desson J., Desvigne G., Deville E., Dewitte A., Dhaoui T., Didier-Wright C., Dieckmann K., Doit C., Dolfi Fiette H., Dolhem P., Dommergues M.A., Dorangeon E., Doucet-Populaire F., Dubois F., Dubourdieu B., Ducrocq S., Dudin A., Dufour M.J., Dumoulard B., Dupre J.M., Durand M.F., Duthilly A., Dutron S., Duval V., Eicher E., Eitenschenck L., El Hamri M., Elena-Daumas M., Elharrif Z., Elias O., Emond J.P., Enchery S., Epaud R., Escoba S., Estapa L., Esteve V., Estevez C., Etienne J., Evers A., Evrard D., Evreux F., Eyer D., Eyssette-Guerreau S., Fabbro C., Faibis F., Fargeot Espaliat A., Farges A., Farhat S., Faul V., Favaretto G., Favier M., Faye A., Feldmann M., Ferey J., Ferroni A., Fiette H., Filippi J.F., Filleron A., Flipo J.L., Flurin V., Foca M., Foix L., Fos M.P., Francois-Chervet C., Frey U., Gaillard J.L., Gaillot T., Gajdos V., Gallet S., Gallou G., Ganivala I., Garandeau C., Garbarg-Chenon A., Garcera Y., Garcia Sanchez C., Garnier F., Garrabe E., Gaschet A., Gaschignard J., Gascoin G., Gaudelus J., Gauduchon V., Gavignet M., Geffroy F., Geniez L., Georget E., Gerard S., Geraud J., Ghosn E., Giacobbi Milet V., Gilles I., Gillet Y., Giorgi C., Girard F., Girard J., Giraudon A., Giroux N., Glatz I., Gleize E., Gobet S., Goguelin A., Goissen C., Goudeau A., Gougeon A., Goumy P., Gouraud F., Gouriet F., Goux A., Grailles A., Graine H., Grancher C., Grando A., Gras-LE-Guen C., Greco M., Gressier B., Grimal I., Grimprel E., Grise G., Gruss R., Guerin F., Guibert S., Guichard H., Guiddir T., Guiet P., Guigonis V., Guilbert J., Guillermet Fromentin C., Guilluy O., Guitton C., Haas A., Haas H., Habib A., Hachani A., Hachem G., Hadjadj S., Haegy-Doehring I., Hage M., Hage Chehade M., Hallage H., Hallalel F., Halna M., Hamdad F., Haouisee S., Harchaoui S., Hatahet R., Hay F., Hedjem N., Hees L., Heidt A., Hentgen V., Heraud M.C., Herve C., Heurte J., Heusse E., Heyman R., Hivert C., Hochart A.C., Hombrouck-Alet C., Honoré S., Horea C., Hubert N., Hubert P., Huet F., Huin N., Huvenne H., Idres N., Ikounga P., Ingrao T., Irakotoh J., Jacob J.L., Jacquet C., Jalloul M., Jan D., Jaouen A.C., Jarlier V., Jarreau P.H., Jaulhac B., Javouhey E., Jehan J., Jensen C., Jeziorski E., Jokic M., Joly-Guillou M.L., Joly-Sanchez L., Joram N., Jorion C., Jullian E., Juvin M.E., Kalach N., Kayal S., Khaled M., Khalfi A., Khorsi S., Kieffer F., Kitzis M.D., Kom R., Kone-Paut I., Kovacs T., Kozisek S., Kucerova J., Kuntzel B., Labarthe F., Labenne M., Laborie M.J., Labrune P., Lacroix D., Lafendi A., Lagier E., Lagier J., Lagree M., Lahrach H., Laidj X, Laisney N., Lakhdari M., Lamant M., Lamarcq M., Lambert C., Lamoureux S., Landragin D., Lanotte P., Laoudi Y., Lapeyre D., Lapeyre F., Lapostolle C., Laugel V., Laulan A., Launay E., Lavigne J.P., LE Bideau M., LE Coustumier A., Leboucher B., Lecine T., Ledru S., Lefevre F., Legagneur M., Legalle M.A., Leger P.L., Legros A., Lehours P., Lelievre N., Lelioux J., Leluan P., Lemaitre N., Lemarié C., Lemble C., Lemenand O., Leneveu M., Leotard S., Lepage J., Leret N., Lerouge-Bailhache M., Leroux P., Lesage F., Lescanne E., Letellier C., Leteurtre S., Letreust M., Leuvrey M., Levast M., Levy M., Levy M., Levy P.Y., Lienhardt A., Ligios A., Long L., Lorrot M., Louf S., Loznewski A., Lureau P., Maakaroun-Vermesse Z., Macchi P., Madhi F., Mager G., Magny J.F., Malige L., Mammes O., Mandelcwajg A., Mandjee A., Mangeol A., Manin C., Mansir T., Manteau C., Marcou V., Marguet C., Mariette S., Marin M., Marmonier A., Marret S., Martha S.A., Martin C., Martinat L., Martinez Ozenda M., Marty S., Masserot C., Mathieu L., Mathieu P., Matoussi Z., Maugard T., Maurin D., Mazataud R., Mazeghrane M., M'bamba C., Mellier J., Melon M., Menager C., Menguy A.C., Menouar M., Menouni-Foray O., Merlin E., Merlot E., Mermet Jeanvoine F., Mermond S., Meslin P., Meunier P., Mezgueldi E., Micaelo M., Michel F., Mignard S., Mignot L., Mikail I., Milcent K., Milh M., Milleret-Proyart M.J., Millou C., Minodier P., Monceau L., Moquet O., Moreigne M., Morisot C., Morle S., Mornand P., Moulene E., Moulin P., Mouly L., Mowendabeka A., Muller S., Murbach V., Nakhleh J., Nathanson S., Naudot X., Navarro C., Nemes R., Neri Schiavini D., Nerome S., Neuwirth C., Ngalula G., Nguyen D.J., Nicola N., Ninot A., Nobili-Dubarry C., Noulard M.N., Osman H., Osman Z., Ould Hocine H., Ouldali N., Oulebsir A., Oules O., Ouziel A., Pages A.S., Pages M.C., Paget C., Palette X., Pancher M., Pantalone L., Paon J.C., Pateyron F., Patoz P., Paul G., Paul J.G., Pauquet E., Peigne C., Pejoan H., Pellegrino B., Pelloux I., Penaud A., Penel D., Pere B., Perez N., Perrier C., Pesenti D., Petitboulanger N., Phan F., Pharaon I., Pierre M.H., Pierrejean D., Pietrement C., Pina P., Pindi B., Pinlou E., Pinquier D., Pinturier M.F., Plaisant F., Planchenault D., Plassart C., Ploton M.C., Plouvier E., Poggioli I., Poilane I., Pons C., Porcheret Huong T.N., Pordes C., Pouessel G., Poyard C., Pradeaux L., Prere F., Priqueler L., Prudent M., Queinnec C., Raber C., Ragot J., Raignoux J., Raobison A., Raoult D., Rault J.P., Ravanel N., Raymond J., Raynaud M.F., Rebaud P., Renaud V., Rennes X, Retornaz K., Rey A., Richardin F., Richelme C., Rimet Y., Rimpici D., Riviere B., Robert B., Roche C., Rolland C., Romain O., Romeo B., Ros B., Roubin D., Roudaut V., Roudiere L., Rouget S., Rougier C., Roullaud S., Roullet Renoleau N., Rousseau F., Roussellier P., Roux A.L., Roybet D., Roze J.C., Rozental J., Sadik A., Saf M., Said-Menthon M.H., Sakr S., Salomez S., Salomon C., Sanchez R., Sarlangue J., Sarthou L., Sartre J., Saumureau S., Savoy I., Scat Y., Schaefer J.L., Schneider F., Schneider J.M., Schvartz M., Schweitzer C., Sebag O., See H., Sevin O., Seys E., Sfez A., Shawali C., Simon L., Simonin C., Siouala B., Sivadon-Tardy V., Smati S., Smets A., Sommabere A., Soto B., Soustelle N., Stefaniuk J., Stephan R., Surdu A., Sweertvaegher A., Szulc M., Tahiri C., Tahraoui S.L., Tamine M., Tauzin M., Tchanga J.P., Terki M., Tete C., Texier A., Therond P., Thibault M., Thieblemont M., Thiriez G., Thore J., Thouvenin M., Tiry C., Tisserand E., Tissieres P., Tixier A., Toubiana J., Touroult-Jupin P., Toyer A.L., Tran T.A., Trentesaux A.S., Tronc F., Truong J., Ursulescu N., Vachee A., Vaillant C., Valade A., Valayer P., Valensi M., Vallee E., Vallet C., VAN DE Perre P., Vandenesch F., Vanel N., Vaucel J., Veauvy-Juven A., Venot C., Verdan M., Verdet C., Vergnaud M., Vergne C., Vernet-Garnier V., Vervel C., Viala C., Vialette V., Vic P., Vignaud O., Violette J., Vittecoq C., Vu Thien H., Wasels R., Wiedemann-Fode A., Worcel I., Yangui M.A., Youssef William W.A., Ythier H., Zarzour A., Zelinsky-Gurung A., Zemouri N., Zenkhri F., Zimmermann B., Zini J.
ISSN
2352-4650 (Electronic)
ISSN-L
2352-4642
Publication state
Published
Issued date
04/2025
Peer-reviewed
Oui
Editor
Abadie V Abdanne M. Abdelhadi M. Aberrane S. Ackermann S. Adam M. N. Adamon L. Adi G. Akitani S. Al Jazayri Z. Al Junaidi A. Al Mazini C. Alba-Sauviat C. Albertini M. T. Allia A. Allouche C. Amama H. Amara M. Amirault P. Amsallem D. Andre M. Andriantahina I. Anxionnat R. Arlet G. Armouche S. Astruc D. Auburtin B. Audry Degardin E. Autret F. Ayadi N. Ayaz-Bensultana N. Bachelier M. N. Baleine J. Balitalike J. Bandin O. Banegas D. Banerjee A. Baret M. Barnaud G. Baron-Joly S. Barrans A. Barrey C. Barsotti K. Barthez M. A. Baruteau R. Basmaci R. Bassil J. Battaglini P. Beaumier S. Bednarek N. Belgaid A. Belivier E. Bellulo S. Ben Said M. Benabdelmalek F. Benbih M. Benchekroun K. Benezech C. Bengrina M. Benmahammed A. Benmonsour L. Benmoulai I. Benoist G. Benoit C. Bensaid P. Benseddik Z. Berche P. Beretta-Salaun G. Bergounioux J. Berneau P. Berterottiere D. Bertrou A. Biessy H. Bilger M. Billaud N. Billion P. Bina A. Bineau P. Biran V. Blacnkaert C. Blanc P. Blanc S. Blasquez A. Blondel E. Blondin G. Blot N. Boileau P. Boize P. Bolot P. Bonacorsi S. Bongo Boina R. Bonnin M. Boquet P. Bosdure E. Bosi C. Bost-Bru C. Boukezia N. Boukhris S. Boulard S. Boulfoul D. Boumecid H. Bour J. Bourennane M. Bourgeois-Nicolaos N. Boussadia H. Boussard N. Boussicault G. Boutry M. Bouvy E. Boyer S. Branger C. Brechet C. Bresson V. Breuil J. Briennon C. Brieu N. Brisset S. Brocard A. Broenen E. Brouard J. Bruna A. L. Bucher J. Bueno B. Buisson-Touati C. Butin M. Cabaret B. Cadot L. Caillon J. Callamand P. Cambon D. Cambonie G. Canis F. Canzi A. M. Capdeville Carbajal R. Carbonnelle B. Carre-Cavellier J. Carrer A. Carriere C. Carroger G. Cartier-Riviere B. Cascarigny F. Casha P. Castelnau P. Cattoen C. Cattoir V. Caurier B. Cavalier A. Cazau C. Cecille A. Celton G. Chaabane A. Chabrol B. Chace A. Chahine J. Chaix Y. Chalumeau M. Chalvon Demersay A. Chamouilli J. M. Champion V. Chantelat P. Chantreuil J. Chaplain C. Charachon S. Charbonneau A. Chardon H. Charpentier S. Charreton C. Chellun P. Chenel C. Cheron M. Cheuret E. Chevallier B. Chevrel J. Chevret L. Chognot D. Chomienne F. Chosidow A. Chrisment D. Ciupek C. Clair P. Claris O. Clavel C. Cochat P. Coche D. Coinde E. Colombani J. C. Combe J. C. Cordier A. M. Cormier P. Corniau F. Costa G. Costa Y. Cottin J. Coumenges P. Courcol R. Courdavault L. Courouble G. Courtade H. Coutable A. Craiu I. Crepet F. D. A. E. Daire-Chabanon I. Dalmon F. Danan C. Danekova N. Danjean-Deguin M. P. Danquigny A. L. Dao-Dubremetz A. Daoud P. Daoudi F. Darai E. Darnaud C. Darras J. P. Dassieu G. Dauger S. D. E. Barbentane M. C. D. E. Champs C. D. E. Decker L. D. E. Montclos H. D. E. Pontual L. Debriel D. Decoster A. Degas V. Delacour T. Delafay M. Delamare C. Delaporte G. Delarbre J. M. Delavelle C. Delbeke E. Delesalle S. Deligne D. Delimele M. Delorme D. Deluca D. Delvart C. Demachy M. C. Demarcq M. J. Demarque N. Demayer N. Demay-Legros G. Demonchy D. Desbois D. Deschamps N. Desfrere L. Deshayes D. E. Cambronne R. Desse B. Dessein R. Dessioux E. Desson J. Desvigne G. Deville E. Dewitte A. Dhaoui T. Didier-Wright C. Dieckmann K. Doit C. Dolfi Fiette H. Dolhem P. Dommergues M. A. Dorangeon E. Doucet-Populaire F. Dubois F. Dubourdieu B. Ducrocq S. Dudin A. Dufour M. J. Dumoulard B. Dupre J. M. Durand M. F. Duthilly A. Dutron S. Duval V. Eicher E. Eitenschenck L. El Hamri M. Elena-Daumas M. Elharrif Z. Elias O. Emond J. P. Enchery S. Epaud R. Escoba S. Estapa L. Esteve V. Estevez C. Etienne J. Evers A. Evrard D. Evreux F. Eyer D. Eyssette-Guerreau S. Fabbro C. Faibis F. Fargeot Espaliat A. Farges A. Farhat S. Faul V. Favaretto G. Favier M. Faye A. Feldmann M. Ferey J. Ferroni A. Fiette H. Filippi J. F. Filleron A. Flipo J. L. Flurin V. Foca M. Foix L. Fos M. P. Francois-Chervet C. Frey U. Gaillard J. L. Gaillot T. Gajdos V. Gallet S. Gallou G. Ganivala I. Garandeau C. Garbarg-Chenon A. Garcera Y. Garcia Sanchez C. Garnier F. Garrabe E. Gaschet A. Gaschignard J. Gascoin G. Gaudelus J. Gauduchon V. Gavignet M. Geffroy F. Geniez L. Georget E. Gerard S. Geraud J. Ghosn E. Giacobbi Milet V. Gilles I. Gillet Y. Giorgi C. Girard F. Girard J. Giraudon A. Giroux N. Glatz I. Gleize E. obet S. Goguelin A. Goissen C. Goudeau A. Gougeon A. Goumy P. Gouraud F. Gouriet F. Goux A. Grailles A. Graine H. Grancher C. Grando A. Gras- L. E. Guen C. Greco M. Gressier B. Grimal I. Grimprel E. Grise G. Gruss R. Guerin F. Guibert S. Guichard H. Guiddir T. Guiet P. Guigonis V. Guilbert J. Guillermet Fromentin C. Guilluy O. Guitton C. Haas A. Haas H. Habib A. Hachani A. Hachem G. Hadjadj S. Haegy-Doehring I. Hage M. Hage Chehade M. Hallage H. Hallalel F. Halna M. Hamdad F. Haouisee S. Harchaoui S. Hatahet R. Hay F. Hedjem N. Hees L. Heidt A. Hentgen V. Heraud M. C. Herve C. Heurte J. Heusse E. Heyman R. Hivert C. Hochart A. C. Hombrouck-Alet C. Honore S. Horea C. Hubert N. Hubert P. Huet F. Huin N. Huvenne H. Idres N. Ikounga P. Ingrao T. Irakotoh J. Jacob J. L. Jacquet C. Jalloul M. Jan D. Jaouen A. C. Jarlier V. Jarreau P. H. Jaulhac B. Javouhey E. Jehan J. Jensen C. Jeziorski E. Jokic M. Joly-Guillou M. L. Joly-Sanchez L. Joram N. Jorion C. Jullian E. Juvin M. E. Kalach N. Kayal S. Khaled M. Khalfi A. Khorsi S. Kieffer F. Kitzis M. D. Kom R. Kone-Paut I. Kovacs T. Kozisek S. Kucerova J. Kuntzel B. Labarthe F. Labenne M. Laborie M. J. Labrune P. Lacroix D. Lafendi A. Lagier E. Lagier J. Lagree M. Lahrach H. Laidj Laisney N. Lakhdari M. Lamant M. Lamarcq M. Lambert C. Lamoureux S. Landragin D. Lanotte P. Laoudi Y. Lapeyre D. Lapeyre F. Lapostolle C. Laugel V. Laulan A. Launay E. Lavigne J. P. L. E. Bideau M. L. E. Coustumier A. Leboucher B. Lecine T. Ledru S. Lefevre F. Legagneur M. Legalle M. A. Leger P. L. Legros A. Lehours P. Lelievre N. Lelioux J. Leluan P. Lemaitre N. Lemarie C. Lemble C. Lemenand O. Leneveu M. Leotard S. Lepage J. Leret N. Lerouge-Bailhache M. Leroux P. Lesage F. Lescanne E. Letellier C. Leteurtre S. Letreust M. Leuvrey M. Levast M. Levy M. Levy M. Levy P. Y. Lienhardt A. Ligios A. Long L. Lorrot M. Louf S. Loznewski A. Lureau P. Maakaroun-Vermesse Z. Macchi P. Madhi F. Mager G. Magny J. F. Malige L. Mammes O. Mandelcwajg A. Mandjee A. Mangeol A. Manin C. Mansir T. Manteau C. Marcou V. Marguet C. Mariette S. Marin M. Marmonier A. Marret S. Martha S. A. Martin C. Martinat L. Martinez Ozenda M. Marty S. Masserot C. Mathieu L. Mathieu P. Matoussi Z. Maugard T. Maurin D. Mazataud R. Mazeghrane M. M'bamba C. Mellier J. Melon M. Menager C. Menguy A. C. Menouar M. Menouni-Foray O. Merlin E. Merlot E. Mermet Jeanvoine F. Mermond S. Meslin P. Meunier P. Mezgueldi E. Micaelo M. Michel F. Mignard S. Mignot L. Mikail I. Milcent K. Milh M. Milleret-Proyart M. J. Millou C. Minodier P. Monceau L. Moquet O. Moreigne M. Morisot C. Morle S. Mornand P. Moulene E. Moulin P. Mouly L. Mowendabeka A. Muller S. Murbach V. Nakhleh J. Nathanson S. Naudot X. Navarro C. Nemes R. Neri Schiavini D. Nerome S. Neuwirth C. Ngalula G. Nguyen D. J. Nicola N. Ninot A. Nobili-Dubarry C. Noulard M. N. Osman H. Osman Z. Ould Hocine H. Ouldali N. Oulebsir A. Oules O. Ouziel A. Pages A. S. Pages M. C. Paget C. Palette X. Pancher M. Pantalone L. Paon J. C. Pateyron F. Patoz P. Paul G. Paul J. G. Pauquet E. Peigne C. Pejoan H. Pellegrino B. Pelloux I. Penaud A. Penel D. Pere B. Perez N. Perrier C. Pesenti D. Petitboulanger N. Phan F. Pharaon I. Pierre M. H. Pierrejean D. Pietrement C. Pina P. Pindi B. Pinlou E. Pinquier D. Pinturier M. F. Plaisant F. Planchenault D. Plassart C. Ploton M. C. Plouvier E. Poggioli I. Poilane I. Pons C. Porcheret Huong T. N. Pordes C. Pouessel G. Poyard C. Pradeaux L. Prere F. Priqueler L. Prudent M. Queinnec C. Raber C. Ragot J. Raignoux J. Raobison A. Raoult D. Rault J. P. Ravanel N. Raymond J. Raynaud M. F. Rebaud P. Renaud V. Rennes Retornaz K. Rey A. Richardin F. Richelme C. Rimet Y. Rimpici D. Riviere B. Robert B. Roche C. Rolland C. Romain O. Romeo B. Ros B. Roubin D. Roudaut V. Roudiere L. Rouget S. Rougier C. Roullaud S. Roullet Renoleau N. Rousseau F. Roussellier P. Roux A. L. Roybet D. Roze J. C. Rozental J. Sadik A. Saf M. Said-Menthon M. H. Sakr S. Salomez S. Salomon C. Sanchez R. Sarlangue J. Sarthou L. Sartre J. Saumureau S. Savoy I. Scat Y. Schaefer J. L. Schneider F. Schneider J. M. Schvartz M. Schweitzer C. Sebag O. See H. Sevin O. Seys E. Sfez A. Shawali C. Simon L. Simonin C. Siouala B. Sivadon-Tardy V. Smati S. Smets A. Sommabere A. Soto B. Soustelle N. Stefaniuk J. Stephan R. Surdu A. Sweertvaegher A. Szulc M. Tahiri C. Tahraoui S. L. Tamine M. Tauzin M. Tchanga J. P. Terki M. Tete C. Texier A. Therond P. Thibault M. Thieblemont M. Thiriez G. Thore J. Thouvenin M. Tiry C. Tisserand E. Tissieres P. Tixier A. Toubiana J. Touroult-Jupin P. Toyer A. L. Tran T. A. Trentesaux A. S. Tronc F. Truong J. Ursulescu N. Vachee A. Vaillant C. Valade A. Valayer P. Valensi M. Vallee E. Vallet C. V. A. N. D. E. Perre P. Vandenesch F. Vanel N. Vaucel J. Veauvy-Juven A. Venot C. Verdan M. Verdet C. Vergnaud M. Vergne C. Vernet-Garnier V. Vervel C. Viala C. Vialette V. Vic P. Vignaud O. Violette J. Vittecoq C. Vu Thien H. Wasels R. Wiedemann-Fode A. Worcel I. Yangui M. A. Youssef William W. A. Ythier H. Zarzour A. Zelinsky-Gurung A. Zemouri N. Zenkhri F. Zimmermann B. Zini J.
Volume
9
Number
4
Pages
255-261
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Comparative Study
Publication Status: ppublish
Publication Status: ppublish
Abstract
Pneumococcal meningitis is a leading cause of bacterial meningitis and the most deadly pneumococcal disease in children worldwide. There is a paucity of evidence concerning the benefit of dexamethasone to prevent death in paediatric pneumococcal meningitis. We aimed to compare the effect of early adjunctive therapy with dexamethasone versus no dexamethasone on death in children with pneumococcal meningitis.
We did a non-randomised, comparative, multicentre, retrospective, quasi-experimental, propensity score-based study using data from a French national surveillance system of pneumococcal meningitis in children that collates data for 238 French paediatric wards working with 168 microbiology laboratories. We compared outcomes of adjunctive therapy with dexamethasone treatment (0·15 mg/kg every 6 h, for 4 days, per national guidelines) given within 12 h of antibiotic treatment versus no dexamethasone among all children aged 0-17 years with confirmed pneumococcal meningitis who had been hospitalised in one of the participating centres between Jan 1, 2005, and Nov 1, 2022. The primary outcome was 30-day all-cause death after hospital admission. The main propensity score analysis was based on inverse probability treatment weighting (IPTW), allowing adjustment for initial severity and baseline characteristics. Sensitivity analyses, such as propensity score matching, were done to assess the robustness of the results.
Between Jan 1, 2005, and Nov 1, 2022, 1765 cases of pneumococcal meningitis were reported to the National Surveillance System of Paediatric Bacterial Meningitis. 534 were excluded from the analysis and 1231 were included, with a median age of 1·1 years (IQR 0·5-5·0, range 0-17·9). 495 (40%) of 1231 patients were female, 716 (58%) were male, and 20 (1%) were missing data for sex. 650 (53%) of 1231 children received dexamethasone and 581 (47%) children did not receive dexamethasone. 108 (9%) of 1231 patients died. Within 30 days of hospitalisation, 105 (9%) patients died, 36 (6%) of 650 in the dexamethasone group and 69 (12%) of 581 in the no dexamethasone group. After IPTW, the adjusted 30-day death rate was 6% in the dexamethasone group and 12% in the no dexamethasone group (marginal odds ratio 0·39, 95% CI 0·23-0·65). All sensitivity analyses gave similar results.
Adjunctive dexamethasone within 12 h of starting antibiotic treatment was associated with a reduced 30-day risk of death in children hospitalised with pneumococcal meningitis. Our findings support the use of dexamethasone to reduce the risk of death in paediatric pneumococcal meningitis.
Pfizer, ACTIV, and National Institute of Health and Medical Research (Inserm) Centre.
We did a non-randomised, comparative, multicentre, retrospective, quasi-experimental, propensity score-based study using data from a French national surveillance system of pneumococcal meningitis in children that collates data for 238 French paediatric wards working with 168 microbiology laboratories. We compared outcomes of adjunctive therapy with dexamethasone treatment (0·15 mg/kg every 6 h, for 4 days, per national guidelines) given within 12 h of antibiotic treatment versus no dexamethasone among all children aged 0-17 years with confirmed pneumococcal meningitis who had been hospitalised in one of the participating centres between Jan 1, 2005, and Nov 1, 2022. The primary outcome was 30-day all-cause death after hospital admission. The main propensity score analysis was based on inverse probability treatment weighting (IPTW), allowing adjustment for initial severity and baseline characteristics. Sensitivity analyses, such as propensity score matching, were done to assess the robustness of the results.
Between Jan 1, 2005, and Nov 1, 2022, 1765 cases of pneumococcal meningitis were reported to the National Surveillance System of Paediatric Bacterial Meningitis. 534 were excluded from the analysis and 1231 were included, with a median age of 1·1 years (IQR 0·5-5·0, range 0-17·9). 495 (40%) of 1231 patients were female, 716 (58%) were male, and 20 (1%) were missing data for sex. 650 (53%) of 1231 children received dexamethasone and 581 (47%) children did not receive dexamethasone. 108 (9%) of 1231 patients died. Within 30 days of hospitalisation, 105 (9%) patients died, 36 (6%) of 650 in the dexamethasone group and 69 (12%) of 581 in the no dexamethasone group. After IPTW, the adjusted 30-day death rate was 6% in the dexamethasone group and 12% in the no dexamethasone group (marginal odds ratio 0·39, 95% CI 0·23-0·65). All sensitivity analyses gave similar results.
Adjunctive dexamethasone within 12 h of starting antibiotic treatment was associated with a reduced 30-day risk of death in children hospitalised with pneumococcal meningitis. Our findings support the use of dexamethasone to reduce the risk of death in paediatric pneumococcal meningitis.
Pfizer, ACTIV, and National Institute of Health and Medical Research (Inserm) Centre.
Keywords
Humans, Dexamethasone/therapeutic use, Dexamethasone/administration & dosage, Meningitis, Pneumococcal/drug therapy, Meningitis, Pneumococcal/mortality, Child, Preschool, Female, Child, Male, Retrospective Studies, Infant, Propensity Score, Adolescent, Anti-Bacterial Agents/therapeutic use, Hospitalization/statistics & numerical data, France/epidemiology, Infant, Newborn, Cause of Death
Pubmed
Create date
24/03/2025 16:20
Last modification date
25/03/2025 8:04
Usage data
