Poly-N-acetyl glucosamine nanofibers for negative-pressure wound therapies.

Details

Serval ID
serval:BIB_FFDE769AA207
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Poly-N-acetyl glucosamine nanofibers for negative-pressure wound therapies.
Journal
Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Author(s)
Fulco I., Erba P., Valeri R.C., Vournakis J., Schaefer D.J.
ISSN
1524-475X (Electronic)
ISSN-L
1067-1927
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
23
Number
2
Pages
197-202
Language
english
Notes
Publication types: Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The wound healing promoting effect of negative wound pressure therapies (NPWT) takes place at the wound interface. The use of bioactive substances at this site represents a major research area for the development of future NPWT therapies. To assess wound healing kinetics in pressure ulcers treated by NPWT with or without the use of a thin interface membrane consisting of poly-N-acetyl glucosamine nanofibers (sNAG) a prospective randomized clinical trial was performed. The safety of the combination of NPWT and sNAG was also assessed in patients treated with antiplatelet drugs. In the performed study, the combination of NPWT and sNAG in 10 patients compared to NPWT alone in 10 patients promoted wound healing due to an improved contraction of the wound margins (p = 0.05) without a change in wound epithelization. In 6 patients treated with antiplatelet drugs no increased wound bleeding was observed in patients treated by NPWT and sNAG. In conclusion, the application of thin membranes of sNAG nanofibers at the wound interface using NPWT was safe and augmented the action of NPWT leading to improved wound healing due to a stimulation of wound contraction.
Keywords
Acetylglucosamine/therapeutic use, Adult, Aged, Aged, 80 and over, Female, Granulation Tissue/pathology, Humans, Male, Middle Aged, Nanofibers/therapeutic use, Negative-Pressure Wound Therapy, Photography, Pressure Ulcer/pathology, Pressure Ulcer/therapy, Prospective Studies, Treatment Outcome, Wound Healing
Pubmed
Web of science
Create date
13/07/2015 11:53
Last modification date
20/08/2019 16:30
Usage data