Transplantation tolerance: Clinical potential of regulatory T cells.

Détails

ID Serval
serval:BIB_FF871871F12F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Transplantation tolerance: Clinical potential of regulatory T cells.
Périodique
Self/nonself
Auteur(s)
Muller Y.D., Seebach J.D., Bühler L.H., Pascual M., Golshayan D.
ISSN
1938-2049 (Electronic)
ISSN-L
1938-2030
Statut éditorial
Publié
Date de publication
2011
Volume
2
Numéro
1
Pages
26-34
Langue
anglais
Notes
Publication types: JOURNAL ARTICLE
Publication Status: ppublish
Résumé
The major challenge in transplantation medicine remains long-term allograft acceptance, with preserved allograft function under minimal chronic immunosuppression. To safely achieve the goal of sustained donor-specific T and B cell non-responsiveness, research efforts are now focusing on therapies based on cell subsets with regulatory properties. In particular the transfusion of human regulatory T cells (Treg) is currently being evaluated in phase I/II clinical trials for the treatment of graft versus host disease following hematopoietic stem cell transplantation, and is also under consideration for solid organ transplantation. The purpose of this review is to recapitulate current knowledge on naturally occurring as well as induced human Treg, with emphasis on their specific phenotype, suppressive function and how these cells can be manipulated in vitro and/or in vivo for therapeutic purposes in transplantation medicine. We highlight the potential but also possible limitations of Treg-based strategies to promote long-term allograft survival. It is evident that the bench-to-beside translation of these protocols still requires further understanding of Treg biology. Nevertheless, current data already suggest that Treg therapy alone will not be sufficient and needs to be combined with other immunomodulatory approaches in order to induce allograft tolerance.
Mots-clé
Allorecognition, Transplantation tolerance, T-cells, Regulatory T-cells
Pubmed
Création de la notice
04/04/2009 11:44
Dernière modification de la notice
20/08/2019 16:29
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