Meta-analysis on survival of patients treated with transoral surgery versus radiotherapy for early-stage squamous cell carcinoma of the oropharynx.

Details

Serval ID
serval:BIB_FF85EB832A97
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Meta-analysis on survival of patients treated with transoral surgery versus radiotherapy for early-stage squamous cell carcinoma of the oropharynx.
Journal
Head & neck
Author(s)
Morisod B., Simon C.
ISSN
1097-0347 (Electronic)
ISSN-L
1043-3074
Publication state
Published
Issued date
04/2016
Peer-reviewed
Oui
Volume
38 Suppl 1
Pages
E2143-50
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Meta-Analysis ; Review ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Transoral surgery (TOS) for patients with early stage oropharyngeal squamous cell carcinoma (SCC) is increasingly used, however, criticized, because of less optimal access to the tumor than open techniques and thus potentially jeopardizing tumor control in comparison with radiotherapy (RT). Therefore, we compared the currently available data on survival provided by TOS versus RT.
Survival data were extracted after a MEDLINE, Web of Science, and Google Scholar search followed by a meta-analysis.
The analysis was based on 729 patients in the RT group versus 276 in the TOS group with similar quality of studies in both groups. The 5-year disease-specific survival (DSS)/overall survival (OS) was 90.4% (95% confidence interval [CI], 85.6% to 95.2%/58.8%; 95% CI, 52.8% to 64.7%) in the RT group versus 89.6% (95% CI, 81.8% to 97.3%/78.1%; 95% CI, 71.2% to 85.1%) in the TOS group.
The data suggest equivalent efficacy of both treatments in terms of disease control for early stage oropharyngeal SCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: 2143-2150.

Keywords
Carcinoma, Squamous Cell/radiotherapy, Carcinoma, Squamous Cell/surgery, Humans, Oropharyngeal Neoplasms/radiotherapy, Oropharyngeal Neoplasms/surgery, Survival Analysis, Treatment Outcome, early stage, meta-analysis, oropharyngeal neoplasm, radiotherapy, transoral surgery
Pubmed
Web of science
Create date
18/10/2016 15:23
Last modification date
20/08/2019 16:29
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