Brain glucose sensing in homeostatic and hedonic regulation.

Détails

ID Serval
serval:BIB_FF757947DDA9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Brain glucose sensing in homeostatic and hedonic regulation.
Périodique
Trends In Endocrinology and Metabolism: Tem
Auteur(s)
Steinbusch L., Labouèbe G., Thorens B.
ISSN
1879-3061 (Electronic)
ISSN-L
1043-2760
Statut éditorial
Publié
Date de publication
2015
Volume
26
Numéro
9
Pages
455-466
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Glucose homeostasis as well as homeostatic and hedonic control of feeding is regulated by hormonal, neuronal, and nutrient-related cues. Glucose, besides its role as a source of metabolic energy, is an important signal controlling hormone secretion and neuronal activity, hence contributing to whole-body metabolic integration in coordination with feeding control. Brain glucose sensing plays a key, but insufficiently explored, role in these metabolic and behavioral controls, which when deregulated may contribute to the development of obesity and diabetes. The recent introduction of innovative transgenic, pharmacogenetic, and optogenetic techniques allows unprecedented analysis of the complexity of central glucose sensing at the molecular, cellular, and neuronal circuit levels, which will lead to a new understanding of the pathogenesis of metabolic diseases.
Mots-clé
Animals, Brain Chemistry/physiology, Energy Metabolism, Food Preferences/physiology, Glucose/metabolism, Homeostasis/physiology, Humans, Neurons/physiology
Pubmed
Web of science
Création de la notice
07/08/2015 11:17
Dernière modification de la notice
20/08/2019 16:29
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