Red cell distribution width and mortality in acute heart failure patients with preserved and reduced ejection fraction.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_FF5E12452638
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Red cell distribution width and mortality in acute heart failure patients with preserved and reduced ejection fraction.
Périodique
ESC heart failure
Auteur(s)
Sotiropoulos K., Yerly P., Monney P., Garnier A., Regamey J., Hugli O., Martin D., Metrich M., Antonietti J.P., Hullin R.
ISSN-L
2055-5822
Statut éditorial
Publié
Date de publication
09/2016
Peer-reviewed
Oui
Volume
3
Numéro
3
Pages
198-204
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Elevated red blood cell distribution width (RDW) is a valid predictor of outcome in acute heart failure (AHF). It is unknown whether elevated RDW remains predictive in AHF patients with either preserved left ventricular ejection fraction (LVEF) ≥50% or reduced LVEF (<50%).
Prospective local registry including 402 consecutive hospitalized AHF patients without acute coronary syndrome or need of intensive care. The primary outcome was all-cause mortality (ACM) at 1 year after admission. Demographic and clinical data derive from admission, echocardiographic examinations (n = 269; 67%) from hospitalization. The Cox proportional hazard model including all patients (P < 0.001) was adjusted for age, gender, and RDW quartiles. Independent predictors of 1-year ACM were cardiogenic shock (HR 2.86; CI: 1.3-6.4), male sex (HR 1.9; CI: 1.2-2.9), high RDW quartile (HR 1.66; CI: 1.02-2.8), chronic HF (HR 1.61; CI: 1.05-2.5), valvular heart disease (HR 1.61; CI: 1.09-2.4), increased diastolic blood pressure (HR 1.02 per mmHg; CI: 1.01-1.03), increasing age (HR 1.04 by year; CI: 1.02-1.07), platelet count (HR 1.002 per G/l; CI: 1.0-1.004), systolic blood pressure (HR 0.99 per mmHg; CI: 0.98-0.99), and weight (HR 0.98 per kg; CI: 0.97-0.99). A total of 114 patients (28.4%) died within the first year; ACM of all patients increased with quartiles of rising RDW (χ(2) 18; P < 0.001). ACM was not different between RDW quartiles of patients with reduced LVEF (n = 153; χ(2) 6.6; P = 0.084). In AHF with LVEF ≥50% the probability of ACM increased with rising RDW (n = 116; χ(2) 9.9; P = 0.0195).
High RDW is associated with increased ACM in AHF patients with preserved but not with reduced LVEF in this study population.

Pubmed
Open Access
Oui
Création de la notice
09/12/2016 12:03
Dernière modification de la notice
20/08/2019 17:29
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